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Primary extrarenal papillary type II renal cell carcinoma presenting as a pelvic mass: a case report and review of the literature.
J Surg Case Rep
July 2024
Department of Surgical Oncology, General Anticancer and Oncology Hospital of Athens "Agios Savvas", Alexandras Avenue 171, Athens 115 22, Greece.
We report a case of a 57 years old woman with a solitary mass located in the pelvis diagnosed as an extrarenal papillary renal cell carcinoma, in the absence of a primary renal cancer. The diagnosis was based on cytomorphological features and further confirmed by immunochemistry findings following surgical excision. The hypothesis of a tumor developing in a supernumerary or ectopic kidney was excluded, since no normal renal tissue could be identified in the specimen and in the preoperative computed tomography and MRI images.
View Article and Find Full Text PDFQuantitative assessment of mitophagy in irradiated cancer cells.
Methods Cell Biol
January 2023
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, United States; Sandra and Edward Meyer Cancer Center, New York, NY, United States; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, United States. Electronic address:
Mitophagy is a finely regulated mechanism through which eukaryotic cells selectively dispose of supernumerary, permeabilized or otherwise damaged mitochondria through lysosomal degradation. Dysfunctional mitochondria are prone to release potentially cytotoxic factors including reactive oxygen species (ROS) and caspase activators, such as cytochrome c, somatic (CYCS). Thus, proficient mitophagic responses mediate prominent cytoprotective functions.
View Article and Find Full Text PDFKIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells.
Life Sci Alliance
November 2022
Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Ikoma, Japan.
Clustering of supernumerary centrosomes, which potentially leads to cell survival and chromosomal instability, is frequently observed in cancers. However, the molecular mechanisms that control centrosome clustering remain largely unknown. The centrosomal kinesin KIF24 was previously shown to restrain the assembly of primary cilia in mammalian cells.
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