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Lactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model.
APMIS
January 2025
Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on the utility of some novel proprietary lactam molecules, quorum sensing (QS)-derived halogenated furanones, which act to block the QS pathway, against key fungal pathogens of the skin (Candida albicans, Malassezia furfur and Microsporum gypseum). Moreover, we aimed to assess how these actives performed against complex interkingdom biofilms in a clinically relevant model.
View Article and Find Full Text PDFRecurrent Indolent Keratitis Caused by Achromobacter xylosoxidans: A Case Report and Literature Review.
Cureus
December 2024
Department of Ophthalmology, UT Southwestern Medical Center, Dallas, USA.
An 83-year-old male with a history of radial keratotomy and laser-assisted in situ keratomileusis (LASIK) presented with symptoms of a non-resolving corneal ulcer in the right eye that had been present for five months. The patient was treated with antibacterial, antiviral, and antifungal medications over that period, with multiple recurrences that prompted referral to our tertiary center for management. Following a 48-hour cessation of all medications, a corneal biopsy was performed which grew .
View Article and Find Full Text PDFSilver nanoparticles coated with metabolites of Pseudomonas sp. N5.12 inhibit bacterial pathogens and fungal phytopathogens.
Sci Rep
January 2025
Faculty of Pharmacy, Universidad San Pablo-CEU Universities, 28668-Boadilla del Monte, Madrid, Spain.
The synthesis of nanomaterials from PGPB is an exciting approach and it's often used in agriculture as nano-fertilizers and nano-pesticides. The present study reports a new approach to biosynthesis of silver nanoparticles (AgNP), using bacterial metabolites as agents to reduce Ag, which will remain as coating agents able to prevent microbial growth. Silver NP were biosynthesized using the bacterial metabolites produced by the beneficial strain Pseudomonas sp.
View Article and Find Full Text PDFRegulatory role of the mTOR signaling pathway in autophagy and mesangial proliferation in IgA nephropathy.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
August 2024
Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011.
Objectives: IgA nephropathy (IgAN) is the most common primary glomerular disease in China, but its pathogenesis remains unclear. This study aims to explore the regulatory role of the mammalian target of rapamycin (mTOR) signaling pathway in autophagy and mesangial proliferation during renal injury in IgA.
Methods: The activity of mTOR and autophagy was evaluated in kidney samples from IgAN patients and in an IgAN mouse model induced by oral bovine serum albumin and carbon tetrachloride (CCl4) injection.
8-Hydroxyquinoline derivative as a promising antifungal agent to combat ocular fungal infections.
J Med Microbiol
January 2025
Programa de Ps-Graduao em Cincias Farmacuticas, Faculdade de Farmcia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Ocular fungal infections are pathologies of slow progression, occurring mainly in the cornea, but can also affect the entire structure of the eyeball. The main aetiological agents are species of the genera and . Both diagnosis and treatment require speed and effectiveness.
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