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Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Infovital, Envigado, Colombia.
Background: Currently, the diagnosis of Alzheimer's disease dementia (ADD) is determined based on clinical criteria, as well as specific imaging and cerebrospinal fluid (CSF) biomarker profiles. However, healthcare professionals face a variety of challenges that hinder their application, such as the interpretation and integration or large amounts of data derived from neuropsychological assessment, the importance attributed to each source of information and the impact of unknown variables, among others. Therefore, this research focuses on the development of a computerized diagnostic tool based on Artificial Intelligence (AI), to strengthen the capacity of healthcare professionals in the identification and diagnosis of ADD.
View Article and Find Full Text PDFMarine-Derived Compound Targeting mTOR and FGFR-2: A Promising Strategy for Breast, Lung, and Colorectal Cancer Therapy.
Med Chem
January 2025
Integrated Genetics and Molecular Oncology Group, Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamilnadu, 603203, India.
Introduction: The marine habitat is a plentiful source of diverse, active compounds that are extensively utilised for their medicinal properties. Pharmaceutical trends have currently changed towards utilising a diverse range of goods derived from the marine environment.
Method: This study aimed to examine the inhibitory effects of bioactive chemicals derived from marine algae and bacteria.
Technology and Dementia Preconference.
Alzheimers Dement
December 2024
Neurogenetics Working Group, Universidad Científica del Sur, Lima, Peru.
Amerindian (AI) populations are substantially underrepresented in AD genetic studies. The Alzheimer's Disease Sequencing Project (ADSP), a global genetic initiative established by the National Institute of Aging (NIA) is supporting regional initiatives in Latin America and its admixed population. Latin America is the largest recently admixed population, with variable Native American, European, and African ancestry proportions, as result of successive settlements and new massive migrations.
View Article and Find Full Text PDFPSAURON: a tool for assessing protein annotation across a broad range of species.
NAR Genom Bioinform
March 2025
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Evaluating the accuracy of protein-coding sequences in genome annotations is a challenging problem for which there is no broadly applicable solution. In this manuscript, we introduce PSAURON (Protein Sequence Assessment Using a Reference ORF Network), a novel software tool developed to help assess the quality of protein-coding gene annotations. Utilizing a machine learning model trained on a diverse dataset from over 1000 plant and animal genomes, PSAURON assigns a score to coding DNA or protein sequence that reflects the likelihood that the sequence is a genuine protein-coding region.
View Article and Find Full Text PDFWhole-genome automated assembly pipeline for strains from reference, and clinical samples using the integrated CtGAP pipeline.
NAR Genom Bioinform
March 2025
Departments of Medicine and Pediatrics, Division of Infectious Diseases and Global Health, University of California San Francisco School of Medicine, 550 16th Street, 4th Floor Mission Hall, San Francisco, CA, 94158, USA.
Whole genome sequencing (WGS) is pivotal for the molecular characterization of ()-the leading bacterial cause of sexually transmitted infections and infectious blindness worldwide. WGS can inform epidemiologic, public health and outbreak investigations of these human-restricted pathogens. However, challenges persist in generating high-quality genomes for downstream analyses given its obligate intracellular nature and difficulty with propagation.
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