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Scleromyxedema (Arndt - Gottron Syndrome) Developing Under Tenofovir Treatment for Hepatitis B: Unique Presentation in a Bulgarian Patient!
Open Access Maced J Med Sci
March 2019
Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia, Bulgaria.
Background: Scleromyxedema, also referred to as the Arndt-Gottron (S-AG) syndrome or the systemic form of Lichen myxedematosus (LM), is a cutaneous mucinosis with a chronic course and high lethality from systemic involvement of other organs and systems. Interesting in several aspects is the association between scleromyxedema and viral hepatitis about: 1) hepatitis virus infection as a possible etiological factor for the development of scleromyxedema, 2) antiretroviral therapy for the treatment of hepatitis as a method of reversing scleromyxedema and 3) antiviral drugs as inducers of scleromyxedema.
Case Report: We present a 53-year old patient who for nine months had been on tenofovir disoproxil 245 mg (0-0-1) therapy for chronic hepatitis B.
[Arndt-Gottron scleromyxedema. Summary of 2 years treatment].
Wien Klin Wochenschr
December 1997
Abteilung für Innere Medizin-Rheumatologie, Lehrklinik Maribor, Slowenien.
The case of a 53-year-old patient with a 2-year history of Arndt-Gottron scleromyxoedema is reported. Typical lichenoid papules were found clinically, along with infiltration of acid mucopolysaccharides into the skin, which induces extensive elephantine-like thickening and hardening of the skin. The presence of abnormal paraproteins is to be rated as the criterion for the diagnosis of scleromyxoedema.
View Article and Find Full Text PDFA case of papular mucinosis (scleromyxoedema of Arndt-Gottron) in a 64-year-old man is reported. Although a cutaneous mucinosis, the disease is characterized by a number of systemic disorders which determine the course and prognosis of the disease. A survey of 57 reported cases reveals that, in addition to the obligatory paraproteinaemia, neurological (24% of cases), cardiovascular (10%) and myopathic (9%) symptoms are in the foreground.
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