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[Influence of prodigiozan-dependent comuton on the resistance of liver mitochondria against damage by protonofor].
Vestn Ross Akad Med Nauk
September 2014
An effector of tissue stress of hepatocytes, prodigiozan-dependent comuton (PDC), provokes deenergiezation of liver mitochondria, preloaded by Ca2+ ions. In this case a decrease of membrane potential (MP) and Ca2+ efflux by cyclosporine A sensitive mechanism of megapore is observed. If megapore is blocked by cyclosporin A, protonofor FCCP provoked decrease of MP and Ca2+ efflux by cyclosporin A-insensitive mechanism.
View Article and Find Full Text PDF[Intraorganic and intratissue mechanisms of protective action of activated Kupffer cells on hepatocytes].
Vestn Ross Akad Med Nauk
August 2013
Endotoxine activated Kupfer cells release into the intercellular space several mediators which act directly on hepatocytes as well as via stellet cells. In both cases Kupfer cells downregulate hepatocytes as a part of paracrine system. However, downregulated part of liver parenchyma might be extended by several mechanisms.
View Article and Find Full Text PDFThe influence of prodigiozan on the processes of postirradiation recovery of hemopoiesis in long-term bone morrow cultures of two strain mice, having genetic distinctions in the condition of systems of the reparation DNA was investigated. It was showh, that the irradiation of long-term bone morrow cultures of mice reparation-defective strain 101/H resulted in the greater degree damage of early haemopoietic precursors (GM-CFC), reduction of the amount of the immature and of the mature granulocytes and of the decrease of the number of stromall cells in the comparison with the bone morrow of reparation-capable mice (CBA x C57B1)F1. Under the introduction in cultures of prodigiozan for 24 hours prior to an radiation the distinctions of the speed of postirradiation recovery of hemopoiesis substantially smoothed out, and the protective effect of the drag in bone morrow cultures of mice 101/H was comparable to those, marked in bone morrow cultures of reparation-capable strain mice (CBA x C57B1)F1.
View Article and Find Full Text PDFInfluence of prodigiozan in different concentrations on the process of postirradiation recovery of haemopoietic precursors (GM-CFC) and morphologically recognizable elements of the bone marrow were studied in long-term bone marrow cultures during 28 days after 2 Gy gamma-irradiation. Also, prodigiozan was studied for action on the contents of GM-CFC and induction of GM-CSF three, 24 and 48 hours after injection in cultures unexposed to radiation. It is shown that injection of prodigiozan in concentration 0.
View Article and Find Full Text PDF[Functional activity of alveolar macrophages in exacerbation of pulmonary tuberculosis].
Probl Tuberk Bolezn Legk
May 2004
The authors estimated the cellular composition of bronchoalveolar lavage fluid, the functional activity of alveolar macrophages from the recovery of tetrazolium nitroblue (TNB test) in 39 patients with an exacerbation of secondary forms of pulmonary tuberculosis before and after prodigiosane stimulation, made a correlation analysis in order to elucidate the correlations between the parameters of a TNB test and the count of macrophages and neutrophils. On an exacerbation of tuberculosis, the activity of a population of alveolar macrophages did not increase, but in its infiltrative form, it even decreased as compared with the normal values. After prodiogiosane stimulation, the in vitro activity of alveolar macrophages increased by almost 60% in infiltrative tuberculosis and by 100% in fibrocavernous tuberculosis; there was no substantial rise in the activity in tuberculoma.
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