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Platelet rich fibrin three-layer reconstruction of the sellar floor after endoscopic endonasal transsphenoidal approach: technical note and initial experience.
Front Surg
December 2024
Department of Neurosurgery, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.
Background: Cerebrospinal fluid (CSF) leakage frequently complicates endoscopic endonasal transsphenoidal pituitary resections, despite the use of lumbar drains, nasoseptal flaps, or commercial dura sealants. Managing this complication often requires revision surgery and increases the risk of infection. Platelet-rich fibrin (PRF), an affordable autologous biomaterial derived from the patient's blood through short, angulated centrifugation, contains growth factors and leukocytes embedded in a fibrin matrix.
View Article and Find Full Text PDFViscoelastic synthetic antigen-presenting cells for augmenting the potency of cancer therapies.
Nat Biomed Eng
December 2024
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
The use of synthetic antigen-presenting cells to activate and expand engineered T cells for the treatment of cancers typically results in therapies that are suboptimal in effectiveness and durability. Here we describe a high-throughput microfluidic system for the fabrication of synthetic cells mimicking the viscoelastic and T-cell-activation properties of antigen-presenting cells. Compared with rigid or elastic microspheres, the synthetic viscoelastic T-cell-activating cells (SynVACs) led to substantial enhancements in the expansion of human CD8 T cells and to the suppression of the formation of regulatory T cells.
View Article and Find Full Text PDFTherapeutic Leukapheresis in a Pediatric Acute Myeloid Leukemia (AML) Crisis as a Critical Life-Saving Adjunctive Therapy: A Case Report.
Cureus
August 2024
Transfusion Medicine, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Article Synopsis
- Hematological malignancies, like acute myeloid leukemia (AML), can lead to severe complications such as hyperleukocytosis, characterized by dangerously high levels of leukocytes (white blood cells) that increase blood viscosity and disrupt circulation.
- A case report details a six-year-old boy with AML who experienced severe hyperleukocytosis, displaying symptoms like high fever and respiratory distress, necessitating urgent medical intervention.
- Therapeutic leukapheresis successfully reduced the patient's leukocyte count by 81% without side effects, leading to significant health improvements and stabilization, highlighting this procedure's critical role in treating pediatric leukemia emergencies.
Study of some components of the influence and formation of blood flow in patients with "slow flow".
Clin Hemorheol Microcirc
December 2024
European University, Tbilisi, Georgia.
Background: "Slow flow" is one very important concept in modern fundamental and clinical biomedicine. Slow coronary flow is indicative of delayed filling of the terminal coronary artery vessels, occurring in the absence of significant coronary stenosis. This group patient of patients exhibits a high incidence of disability and represents a significant financial and material burden for the state and the healthcare system in general.
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