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Radiotherapy of brain metastases in lung cancer.

Folia Med (Plovdiv)

October 2000

Department of Roentgenology and Radiology, Higher Medical Institute, Plovdiv, Bulgaria.

Unlabelled: Therapeutical approach in brain metastases still remains the major problem in many cancer patients, especially in those with primary lung lesion. The aim of the present study was to test the tolerance to a whole brain telegammatherapy with a daily dose of 2 Gy in patients with lung cancer, to evaluate the improvement of sensory and motor deficits, and to define the more appropriate total dose (20 or 30 Gy) with regard to the patient survival.

Material And Methods: Thirty nine patients with lung cancer and verified brain metastases underwent a whole brain telegammatherapy to a total dose of 20-30 Gy.

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The levels of T-system lymphocytes, macrophageal transformation of mononuclears and phagocytic activity of blood neutrophils were assayed in 194 patients with endometrial tumors, stage I-IV, (FIGO, 1988), 10-15 days after surgery, a subsequent course of telegammatherapy and 2-3 years after treatment. Ninety-seven patients of the study group were challenged by immunization with a live tularemia vaccine (LTV) 15-20 days before surgery, while the same number of controls were not. The study was randomized.

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A randomized study was carried out of the efficacy of a new procedure of adjuvant immunotherapy for cancer of corpus uteri in conjunction with anticoagulant treatment. Ninety-seven patients (76-stage I-II and 21-stage III-IV) were inoculated tularemia booster (TB) and received fibrinolysin, pelentan and aspirin 15-20 days before combined treatment including uterine extirpation or extirpation with adnexa followed by telegammatherapy. Two groups of identical numbers of patients with an identical distribution of tumor progression stage were used as controls.

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[Comparison of two treatment methods in inoperable primary brain tumors].

Neurol Neurochir Pol

March 1994

Zakładu Onkologii Akademii Medycznej w Lublinie.

The results of two conservative treatment regimens in patients with inoperable brain tumours are presented. The group of 25 patients were treated with protracted telegammatherapy and concomitant multi-drug chemotherapy. Another group of 29 patients were irradiated with shorter series of increasing daily doses, receiving no chemotherapy.

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The authors had 170 patients with retroperitoneal nonorganic tumors under observation. Operations were conducted on 143 patients. Patients with malignant tumors received intensive radiotherapy in a dose of 5Gr every other day to a total dose of 20-30 Gr.

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