Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Tryptophan Metabolites in the Progression of Liver Diseases.
Biomolecules
November 2024
Department of Internal Medicine, Gastroenterology and Hepatology, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
The aim of this study was to investigate the levels of various tryptophan metabolites in patients with alcoholic liver disease (ALD) and metabolic-associated fatty liver disease (MAFLD) at different stages of the disease. The present study included 44 patients diagnosed with MAFLD, 40 patients diagnosed with ALD, and 14 healthy individuals in the control group. The levels of tryptophan and its 16 metabolites (3-OH anthranilic acid, 5-hydroxytryptophan, 5-methoxytryptamine, 6-hydroxymelatonin, indole-3-acetic acid, indole-3-butyric, indole-3-carboxaldehyde, indole-3-lactic acid, indole-3-propionic acid, kynurenic acid, kynurenine, melatonin, quinolinic acid, serotonin, tryptamine, and xanthurenic acid) in the serum were determined via high-performance liquid chromatography and tandem mass spectrometry.
View Article and Find Full Text PDFShort communication: An alternative pathway for melatonin synthesis in the skin of European flounder (Platichthys flesus).
Comp Biochem Physiol A Mol Integr Physiol
November 2024
Department of Genetics and Marine Biotechnology, Institute of Oceanology, Polish Academy of Sciences, Powstańców Warszawy 55 Str., 81-712 Sopot, Poland. Electronic address:
The classic melatonin biosynthesis pathway (Mel; N-acetyl-5-methoxytryptamine) involves two consecutive enzymatic steps that are decisive in hormone production: conversion of serotonin (5-hydroxytryptamine; 5-HT) to N-acetylserotonin (NAS) and the methylation of the last compound to Mel. This pathway requires the activity of the enzymes: the first is of the category of N-acetyltransferases (AANAT, SNAT, or NAT) and the second is N-acetylserotonin O-methyltransferase (ASMT; also known as HIOMT). However, quite recently, new information has been provided on the possibility of an alternative Mel synthesis pathway; it would include a two-step action by these enzymes, but in reverse order, where ASMT (or ASMTL, the enzyme related to ASMT) methylates 5-HT to 5-methoxytryptamine (5-MT), and then the last compound is acetylated by an enzyme of the category of N-acetyltransferases to Mel.
View Article and Find Full Text PDFThe Physiological and Molecular Mechanisms of Exogenous Melatonin Promote the Seed Germination of Maize ( L.) under Salt Stress.
Plants (Basel)
August 2024
College of Plant Science and Technology, Beijing University of Agriculture, Beijing 102206, China.
Salt stress caused by high concentrations of Na and Cl in soil is one of the most important abiotic stresses in agricultural production, which seriously affects grain yield. The alleviation of salt stress through the application of exogenous substances is important for grain production. Melatonin (MT, N-acetyl-5-methoxytryptamine) is an indole-like small molecule that can effectively alleviate the damage caused by adversity stress on crops.
View Article and Find Full Text PDFParticipation of Ca-Calmodulin-Dependent Protein Kinase II in the Antidepressant-Like Effects of Melatonin.
Mol Pharmacol
August 2024
Laboratorio de Neurofarmacología (A.M.-R., J.O.-S., J.A., L.A.C.-J., G.B.-K.), Departamento de Neurofisiología, Dirección de Investigaciones en Neurociencias (M.G.C., C.T., R.C.-G.), and Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias (R.E.-R.), Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
Melatonin (-acetyl-5-methoxytryptamine) is an indoleamine secreted by the pineal gland during the dark phase of the photoperiod. Its main function is the synchronization of different body rhythms with the dark-light cycle. Research on melatonin has significantly advanced since its discovery and we now know that it has considerable significance in various physiological processes, including immunity, aging, and reproduction.
View Article and Find Full Text PDFOverexpression of results in various morphological, anatomical, physiological and molecular changes in switchgrass.
Front Plant Sci
June 2024
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Introduction: Melatonin (N-acetyl-5-methoxytryptamine) is a molecule implicated in multiple biological functions, but exerts contrasting effects on plants owing to concentration differences. Hydroxyindole O-methyltransferase (HIOMT), which catalyzes the last step of melatonin synthesis, plays a crucial role in this context.
Methods: Transgenic switchgrass overexpressing with different melatonin levels displayed distinct morphological changes in a concentration-dependent manner.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!