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Approaches to Study Wound-Induced Hair Neogenesis (WIHN).
Methods Mol Biol
July 2024
Department of Life Sciences, Shiv Nadar Institution of Eminence, Greater Noida, Uttar Pradesh, India.
Embryonic wound repair proceeds with complete regeneration of the tissue without any scar formation, whereas tissue repair in adults usually results in scars and the tissue does not completely regain its preinjured state. Wound-induced hair neogenesis (WIHN) in adult rodents results in de novo hair follicle formation in the center of large wounds, mimicking regeneration processes seen in fetal tissue. The investigation of WIHN therefore provides a unique quantitative framework for scrutinizing the mechanistic underpinnings of regenerative repair, which can have clinical implications in the context of scarless healing.
View Article and Find Full Text PDFDecoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish.
Sci Adv
August 2023
Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells in adulthood. Understanding this framework would provide mechanistic insights for β cell regeneration, which may be extrapolated to humans. Here, we characterize a -expressing ductal cell type, which is distinct from the putative Notch-responsive cells, showing neogenic competence and giving rise to the majority of endocrine cells during postembryonic development.
View Article and Find Full Text PDFPax4-Ghrelin mediates the conversion of pancreatic ε-cells to β-cells after extreme β-cell loss in zebrafish.
Development
March 2023
Institute of Developmental Biology and Regenerative Medicine, Southwest University, Beibei 400715 Chongqing, China.
Pancreatic ε-cells producing ghrelin are one type of endocrine cell found in islets, which have been shown to influence other intra-islet cells, especially in regulating the function of β cells. However, the role of such cells during β-cell regeneration is currently unknown. Here, using a zebrafish nitroreductase (NTR)-mediated β-cell ablation model, we reveal that ghrelin-positive ε-cells in the pancreas act as contributors to neogenic β-cells after extreme β-cell loss.
View Article and Find Full Text PDFCXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD.
Cells
February 2023
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
The number of people suffering from hair loss is increasing, and hair loss occurs not only in older men but also in women and young people. Prostaglandin D (PGD) is a well-known alopecia inducer. However, the mechanism by which PGD induces alopecia is poorly understood.
View Article and Find Full Text PDFWound-Induced Hair Neogenesis Model.
J Invest Dermatol
October 2022
Department of Dermatology, Johns Hopkins University, Baltimore, Maryland, USA; Department of Cell Biology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address:
Skin wounds in adult mammals typically heal with a fibrotic scar and fail to restore ectodermal appendages, such as hair follicles or adipose tissue. Intriguingly, new hair follicles regenerate in the center of large full-thickness wounds of mice in a process called wound-induced hair neogenesis (WIHN). WIHN is followed by neogenesis of dermal adipose tissue.
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