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Population pharmacokinetic model of tranexamic acid in patients who undergo cardiac surgery with cardiopulmonary bypass.
Eur J Clin Pharmacol
January 2025
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8560, Japan.
Purpose: Tranexamic acid (TXA) is widely used as an antifibrinolytic drug. However, studies to determine the optimal blood concentration of TXA have produced inconsistent results. During cardiac surgery, cardiopulmonary bypass (CPB) has serious effects on drug distribution, elimination, and plasma concentration.
View Article and Find Full Text PDFDevelopment of a Population Pharmacokinetic Model Characterizing the Tissue Distribution of Resveratrol After Administration by Different Routes and Doses in Rats.
Nutrients
January 2025
School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, Brazil.
Studies have demonstrated that resveratrol exerts several pharmacological effects. However, the pharmacokinetic parameters are not completely established. This study describes the plasma pharmacokinetics and tissue distribution of resveratrol after administration by different routes and doses in rats.
View Article and Find Full Text PDFRadionuclide sorption dynamics in the Rhone River: Experimental and modelling approach.
J Environ Radioact
January 2025
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-ENV/STAAR/LRTA, PSE-ENV/SPDR/LT2S, Saint-Paul-lez-Durance, F-13115, France. Electronic address:
The transfer of radionuclides discharged into rivers by nuclear facilities are conditioned by their solid/liquid fractionation, commonly represented by an equilibrium approach using the distribution coefficient K. This coefficient, largely used in modeling, assumes an instantaneous and completely reversible reaction. However, such assumptions are rarely verified.
View Article and Find Full Text PDFCocktail Effect of 4d/5d Band Twisted High-Entropy Alloys on Carbon Nanotube for Hydrazine Splitting.
Small
January 2025
Department of Chemistry (BK21 FOUR), Research Institute of Natural Sciences, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Article Synopsis
- Multi-walled carbon nanotubes (CNT) are embedded with RuPdIrPtAu high entropy alloys (HEA) using pulsed laser irradiation in liquids, resulting in a composite that enhances hydrazine oxidation reactions (HzOR) for improved water electrolysis.
- HEA particles, sized around 2-5 nm, are effectively dispersed on the CNTs, allowing an optimized variant (HEA/CNT-10) to demonstrate superior performance in oxygen and hydrogen evolution reactions (OER and HER), showing low overpotentials of 30.7 mV for OER and 330 mV for HER.
- The composite exhibits a lower voltage requirement of 0.1 V for HzOR compared to the 1.56
[Source and Health Risk Assessment of Heavy Metals in Groundwater of Datong Basin].
Huan Jing Ke Xue
January 2025
School of Water Resources & Environmental Engineering, East China University of Technology, Nanchang 330013, China.
The identification of distribution characteristics, pollution sources, and potential human health risks of heavy metals in groundwater is crucial for the scientific planning and rational development of groundwater resources in arid-semiarid regions. In this study, 46 groundwater samples were collected and analyzed using hydrogeochemical modeling and multivariate statistical analysis methods to reveal the pollution characteristics and speciation distribution of 11 heavy metals （As, B, Pb, Sb, Tl, Mn, Ba, Cd, Co, Cr, and Al） in the Datong Basin. The absolute principal component-linear regression （APCS-MLR） model and health risk assessment model （HRA） were employed to determine the sources and health risk levels of heavy metals in groundwater.
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