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Development of optical microneedle-lens array for photodynamic therapy.
Biomed Microdevices
January 2025
Institute of Industrial Science, The University of Tokyo, Meguro-Ku, 153-8505, Tokyo, Japan.
Recently, photodynamic therapy (PDT) which involves a photosensitizer (PS), a special drug activated by light, and light irradiation has been widely used in treating various skin diseases such as port-wine stain as well as cancers such as melanoma and non-melanoma skin cancers. PDT comprises two general steps: the introduction of PS into the body or a specific spot to be treated, and the irradiation process using a light source with a specific wavelength to excite the PS. Although PDT is gaining great attention owing to its potential as a targeted approach in the treatment of skin cancers, several limitations still exist for practical use.
View Article and Find Full Text PDFManufacturing of Liposomes Using a Stainless-Steel Microfluidic Device: An Investigation into Design of Experiments.
Langmuir
January 2025
Department of Polymer and Materials Chemistry, Faculty of Chemistry & Petroleum Sciences, Shahid Beheshti University, P.O. Box 1983969411 Tehran, Iran.
Liposomes are highly beneficial nanocarrier systems due to their biocompatibility, low toxicity, and exceptional inclusiveness, which lead to improved drug bioavailability. For biological applications, accurate control over these nanoparticles' mean size and size distribution is essential. Micromixers facilitate the continuous production of liposomes, enhancing the precision of size regulation and reproducibility.
View Article and Find Full Text PDFChitosan-DNA nanoparticles: synthesis and optimization for long-term storage and effective delivery.
PeerJ
January 2025
Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
Background: Chitosan nanoparticles (CsNPs) are an effective and inexpensive approach for DNA delivery into live cells. However, most CsNP synthesis protocols are not optimized to allow long-term storage of CsNPs without loss of function. Here, we describe a protocol for CsNP synthesis, lyophilization, and sonication, to store CsNPs and maintain transfection efficiency.
View Article and Find Full Text PDFPolarization optical coherence tomography optoretinography: verifying light-induced photoreceptor outer segment shrinkage and subretinal space expansion.
Neurophotonics
January 2025
University of Illinois Chicago, Department of Biomedical Engineering, Chicago, Illinois, United States.
Significance: Stimulus-evoked intrinsic optical signal (IOS) changes in retinal photoreceptors are critical for functional optoretinography (ORG). Optical coherence tomography (OCT), with its depth-resolved imaging capability, has been actively explored for IOS imaging of retinal photoreceptors. However, recent OCT studies have reported conflicting results regarding light-induced changes in the photoreceptor outer segments (OSs), with both elongation and shrinkage being observed.
View Article and Find Full Text PDFOptimization of x-ray dark-field CT for human-scale lung imaging.
Med Phys
January 2025
Department of Engineering Physics, Tsinghua University, Beijing, China.
Background: X-ray grating-based dark-field imaging can sense the small angle scattering caused by object's micro-structures. This technique is sensitive to the porous microstructure of lung alveoli and has the potential to detect lung diseases at an early stage. Up to now, a human-scale dark-field CT (DF-CT) prototype has been built for lung imaging.
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