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Coronary vasospasm and cardiovascular outcomes in patients with isolated myocardial bridging: A retrospective study.
Cardiol J
December 2024
Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea.
Article Synopsis
- - The study investigates the link between myocardial bridging (MB) and coronary vasospasm (CVS), aiming to see if CVS worsens outcomes for patients with MB over the long term.
- - Researchers included 254 patients with MB, dividing them into two groups: those with CVS (168 patients) and those without (86 patients), and examined major adverse cardiovascular events (MACEs) over an average follow-up of 8.15 years.
- - Results showed that patients with CVS experienced significantly higher rates of MACEs (35.1%) compared to those without CVS (26.7%), indicating that CVS negatively impacts the clinical outcomes of MB patients, suggesting a need for further research.
Cardiac channelopathies in pediatrics: a genetic update.
Eur J Pediatr
November 2024
Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950, Barcelona, Catalonia, Spain.
Article Synopsis
- - Cardiac channelopathies are inherited syndromes in children that can lead to serious heart issues like malignant arrhythmias and sudden cardiac death, often diagnosed through a 12-lead electrocardiogram.
- - Identifying these conditions early is important, especially since symptoms may only appear after triggers like exercise or emotions; complementary tests, including genetic analysis, can help diagnose and assess risks in affected families.
- - Advances in genetic testing and sequencing technologies are aiding in discovering new genetic causes and refining the interpretation of uncertain genetic variants, crucial for effective risk management in pediatric patients.
Naloxone for cardiac arrest: Provocative results and important new questions (invited commentary).
Resuscitation
September 2024
Department of Emergency Medicine and Rocky Mountain Poison and Drug Safety, Denver Health, Denver, CO, USA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:
A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome.
JAMA
July 2024
Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.
Article Synopsis
- - The text discusses Calcium Release Deficiency Syndrome (CRDS), a serious genetic heart condition that can cause sudden cardiac arrest without clear reasons and is not detectable through standard tests.
- - The study aimed to analyze electrocardiogram (ECG) responses after brief periods of fast heart rates followed by pauses in order to develop a diagnostic test for CRDS.
- - Findings showed that patients with CRDS had a significantly greater change in T-wave amplitude on their ECG after a pause compared to control groups, indicating a potential diagnostic marker for this syndrome.
Case Report: Lacosamide unmasking -associated Brugada syndrome in a young female with epilepsy.
Front Cardiovasc Med
May 2024
Cardiovascular Center, Center of Heart Failure and Center of Genetic Heart Diseases, Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Background: Lacosamide is frequently used as a mono- or adjunctive therapy for the treatment of adults with epilepsy. Although lacosamide is known to act on both neuronal and cardiac sodium channels, potentially leading to cardiac arrhythmias, including Brugada syndrome (BrS), its adverse effects in individuals with genetic susceptibility are less understood.
Case: We report a 33-year-old female with underlying epilepsy who presented to the emergency department with a four-day history of seizure clusters, and was initially treated with lacosamide therapy.
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