Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Glucocorticoids and mineralocorticoids in hair: facilitating accurate diagnosis of adrenal-related endocrine disorders.
Front Endocrinol (Lausanne)
November 2024
Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.
Article Synopsis
- A study was conducted to investigate the presence of mineralocorticoids and glucocorticoids, particularly focusing on aldosterone and 18-hydroxycorticosterone, in hair follicles, which has not been reported before.
- Hair samples from 15 healthy volunteers were analyzed using advanced extraction and mass spectrometry techniques, allowing for the detection of various steroids without significant differences between genders.
- Notable findings included the detection of deoxycortisol, deoxycorticosterone, and 18-hydroxycorticosterone for the first time in hair, showing variability in levels for some steroids but stability in others across individuals.
Prevalence of and factors associated with Na + /K + imbalances in a population of children hospitalized with febrile urinary tract infection.
Eur J Pediatr
December 2024
Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione Ca' Granda IRCCS, Policlinico Di Milano, Milan, Italy.
Article Synopsis
- Researchers looked at children in Italy who were hospitalized for a urinary infection and checked their sodium (Na) and potassium (K) levels.
- They found that 23% of the kids had low sodium, while some had high potassium or both low sodium and high potassium.
- The study also discovered that specific levels in the blood and age were linked to these imbalances, with the most common issue being low sodium.
Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production.
bioRxiv
August 2024
Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA.
The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of the adrenal gland, is a master regulator of plasma electrolytes and blood pressure. While aldosterone control by the renin-angiotensin system is well understood, other key regulatory factors have remained elusive. Here, we replicated a prior association between a non-coding variant in and an increased risk of primary aldosteronism, a prevalent and debilitating disease caused by excessive aldosterone production.
View Article and Find Full Text PDFTransient secondary pseudo-hypoaldosteronism in infants with urinary tract infections: systematic literature review.
Eur J Pediatr
October 2024
Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Della Commenda 9, 20122, Milan, Italy.
Unlabelled: Infants with a congenital anomaly of the kidney and urinary tract sometimes present with hyponatremia, hyperkalemia, and metabolic acidosis due to under-responsiveness to aldosterone, hereafter referred to as secondary pseudo-hypoaldosteronism. The purpose of this report is to investigate pseudo-hypoaldosteronism in infant urinary tract infection. A systematic review was conducted following PRISMA guidelines after PROSPERO (CRD42022364210) registration.
View Article and Find Full Text PDFCalcineurin inhibitor-related hyperkalemia is caused by hyporeninemic hypoaldosteronism and fludrocortisone is an effective treatment: Report of a case series and review of the literature.
Pediatr Transplant
June 2024
Division of Pediatric Endocrinology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Introduction: Calcineurin inhibitors (CNIs) are widely used in transplantation. Although CNI-related hyperkalemia is common (10%-60.6%), the underlying pathogenetic mechanism is not well-elucidated and may lead to dose adjustment or treatment withdrawal.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!