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Ubiquity, Hazardous Effects, and Risk Assessment of Fragrances in Consumer Products.
Curr Treat Options Allergy
January 2021
Dermatology Department, University Hospital of Toledo Complex, Toledo, Spain.
Purpose Of Review: The main aims of fragrances are to create pleasing scents or to mask unpleasant odors. We hereby review their main exposure sources, presumed benefits, and unwanted effects, with special attention to allergic contact dermatitis (prevalence, regulatory environment, risk assessment methodology, and preventive measures).
Recent Findings: Fragrances elicit positive emotions and presumably have therapeutic benefits related to stress reduction and memory enhancement.
A new case of spa dermatitis mimicking photo allergy.
Contact Dermatitis
July 2020
Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France.
Successful photopatch testing with ketoprofen using one-hour occlusion.
Acta Derm Venereol
March 2011
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö, Lund University, SE-205 02 Malmö, Sweden.
The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatch testing with ketoprofen.
View Article and Find Full Text PDFA modified murine local lymph node assay for the differentiation of contact photoallergy from phototoxicity by analysis of cytokine expression in skin-draining lymph node cells.
Toxicology
February 1998
Experimental Toxicology, Novartis Pharma AG, Basel, Switzerland.
Since predictive differentiation of photoallergenic from phototoxic reactions, induced by low molecular weight compounds, represents a current problem, we tried to improve the differentiation between the two reactions by using a modified protocol of the local lymph node assay (LLNA). Briefly, groups of female BALB/c mice received compound solution or vehicle alone on the dorsum of both ears on 3 consecutive days. Immediately after compound application indicated groups of mice were exposed to a UVA light-dose of 10 J/cm2.
View Article and Find Full Text PDFContact and photocontact sensitivity to sunscreens. Review of a 15-year experience and of the literature.
Contact Dermatitis
November 1997
Department of Dermatology, University of Göttingen, Germany.
This review summarizes published and unpublished data of our 15-year experience with sunscreen allergy and photoallergy. From 1981-1996, 402 patients with suspected clinical photosensitivity were patch and photopatch tested with the commercial sunscreens and facial cosmetics that they had used and with chemical UV absorbers, fragrance materials, preservatives, and emollients. 80 patients (20%) (28 men, 52 women) demonstrated allergic and/or photoallergic contact dermatitis to 1 or more UV absorber(s).
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