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Quantitative image signature and machine learning-based prediction of outcomes in cerebral cavernous malformations.
J Stroke Cerebrovasc Dis
January 2024
Department of Neurology, Mayo Clinic, Rochester, MN, United States.
Purpose: There is increasing interest in novel prognostic tools and predictive biomarkers to help identify, with more certainty, cerebral cavernous malformations (CCM) susceptible of bleeding if left untreated. We developed explainable quantitative-based machine learning models from magnetic resonance imaging (MRI) in a large CCM cohort to demonstrate the value of artificial intelligence and radiomics in complementing natural history studies for hemorrhage and functional outcome prediction.
Materials And Methods: One-hundred-eighty-one patients from a prospectively registered cohort of 366 adults with CCM were included.
DIPNECH: pragmatic approach, uncertainties, notable associations, and a proposal for an improved definition.
Endocr Relat Cancer
October 2023
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare, but increasingly recognized entity that primarily affects middle-aged and elderly women. It is characterized by abnormal proliferation of pulmonary neuroendocrine cells (PNECs) and is considered a preinvasive lesion for carcinoid tumorlets/tumors. Sometimes, DIPNECH is accompanied by constrictive bronchiolitis which usually manifests as chronic cough and/or dyspnea, along with airflow limitation on spirometry.
View Article and Find Full Text PDFBackground: Anti-TNFα associated to seton drainage has a central role in the treatment of complex perineal Crohn's fistulas (PAF). A precise treatment protocol is lacking.
Aims: to evaluate the results of this combined treatment and identify predictive factors of response.
Clinico-radiologic features of molar-incisor malformation in a case series of 38 patients: A retrospective observational study.
Medicine (Baltimore)
October 2019
Department of Oral and Maxillofacial Radiology, School of Dentistry and Dental Research Institute, Seoul National University, Republic of Korea.
Molar-incisor malformation (MIM) is a recently defined dental abnormality of molar root and incisors, and introduced as one of the causes of periapical and periodontal abscess. The purpose of this study was to investigate the clinical and radiological features of MIM, with special emphasis on various medical history. A total of 38 patients with MIM were included in this study.
View Article and Find Full Text PDFIDH1 mutation, a genetic alteration associated with adult gliomatosis cerebri.
Neuropathology
February 2012
Laboratory of Pathology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
Recently, mutations in IDH1 and IDH2 have been reported as an early and common genetic alteration in diffuse gliomas, being possibly followed by 1p/19q loss in oligodendrogliomas and TP53 mutations in astrocytomas. Lately, IDH1 mutations have also been identified in adult gliomatosis cerebri (GC). The aim of our study was to test the status of IDH1/2, p53 and of chromosomes 1 and 19 in a series of 12 adult and three pediatric GC.
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