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Enzyme-constrained Metabolic Model of Identified Glycerol-3-phosphate Dehydrogenase as an Alternate Electron Sink.
bioRxiv
November 2024
Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln.
, the causative agent of syphilis, poses a significant global health threat. Its strict intracellular lifestyle and challenges in cultivation have impeded detailed metabolic characterization. In this study, we present iTP251, the first genome-scale metabolic model of , reconstructed and extensively curated to capture its unique metabolic features.
View Article and Find Full Text PDFLimitations of soil-applied non-microbial and microbial biostimulants in enhancing soil P turnover and recycled P fertilizer utilization - a study with and without plants.
Front Plant Sci
November 2024
Institute of Crop Science, Department of Fertilization and Soil Matter Dynamics, University of Hohenheim, Stuttgart, Germany.
Introduction: Phosphorus recovery from waste streams is a global concern due to open nutrient cycles. However, the reliability and efficiency of recycled P fertilizers are often low. Biostimulants (BS), as a potential enhancer of P availability in soil, could help to overcome current barriers using recycled P fertilizers.
View Article and Find Full Text PDFAlkali-Free Oxidation of 1,2-Propanediol to Lactic Acid over Intermetallic CuPt Compounds.
Langmuir
December 2024
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemistry, Zhejiang University, Hangzhou 310028, China.
Article Synopsis
- * Researchers developed a new method using activated carbon-supported Pt-Cu intermetallic compounds to convert 1,2-propanediol (1,2-PDO) directly into lactic acid, achieving a 64.6% yield within 2 hours at 100 °C.
- * The study found that these Pt-Cu intermetallics effectively activated molecular oxygen and 1,2-PDO, facilitating the oxidation process needed to produce lactic acid.
Aerobic Energy Turnover and Exercise Economy Profile During Race Simulation in a World-Record-Breaking Male Full-Distance Triathlete.
Int J Sports Physiol Perform
January 2025
Team Danmark, Brondbyvester, Denmark.
Article Synopsis
- The study investigates the metabolism and exercise efficiency of a top-tier triathlete during extended race simulations lasting over 4 hours to refine training and nutrition strategies.
- The triathlete, preparing for Challenge Roth 2023, underwent two simulated races that included cycling and running, with frequent physiological assessments to measure factors like oxygen uptake and heart rate.
- Results indicated that while carbohydrate utilization was key for energy, the triathlete maintained strong aerobic performance and stable cycling efficiency, though running efficiency slightly declined over time.
High Mitophagy and Low Glycolysis Predict Better Clinical Outcomes in Acute Myeloid Leukemias.
Int J Mol Sci
October 2024
Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale, Via P. Solaroli 17, 28100 Novara, Italy.
Acute myeloid leukemia (AML) emerges as one of the most common and fatal leukemias. Treatment of the disease remains highly challenging owing to profound metabolic rewiring mechanisms that confer plasticity to AML cells, ultimately resulting in therapy resistance. Autophagy, a highly conserved lysosomal-driven catabolic process devoted to macromolecular turnover, displays a dichotomous role in AML by suppressing or promoting disease development and progression.
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