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[Peripheral Nerve and Muscle Disorders Associated with Sjögren's Syndrome].
Brain Nerve
May 2024
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University(TMDU).
Sjögren's syndrome is often accompanied by various neurological complications, among which peripheral neuropathy is the most common. A variety of clinical phenotypes of peripheral neuropathy, including axonal polyneuropathy and sensory ataxic neuropathy are reported in the literature. We present an overview of the pathophysiology and differential diagnosis of each phenotype.
View Article and Find Full Text PDFEvaluation of the diagnostic value of transcranial electrical stimulation (TES) to assess neuronal functional integrity in horses.
Front Neurosci
April 2024
Department of Translational Physiology, Infectiology and Public Health, Research Group of Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Unlabelled: Medical imaging allows for the visualization of spinal cord compression sites; however, it is impossible to assess the impact of visible stenotic sites on neuronal functioning, which is crucial information to formulate a correct prognosis and install targeted therapy. It is hypothesized that with the transcranial electrical stimulation (TES) technique, neurological impairment can be reliably diagnosed.
Objective: To evaluate the ability of the TES technique to assess neuronal functional integrity in ataxic horses by recording TES-induced muscular evoked potentials (MEPs) in three different muscles and to structurally involve multiple ancillary diagnostic techniques, such as clinical neurological examination, plain radiography (RX) with ratio assessment, contrast myelography, and post-mortem gross and histopathological examination.
The gene in neurobiology.
J Neurogenet
March 2024
Université de Lorraine, Laboratoire Stress, Immunité, Pathogènes (EA7300), Faculté de Médecine, Vandœuvre-les-Nancy, France.
is a gene whose alternative splicing yields epithelial, neuronal, and muscular isoforms. The autosomal recessive () spontaneous mouse mutation causes degeneration of spinocerebellar tracts as well as peripheral sensory nerves, dorsal root ganglia, and cranial nerve ganglia. In addition to mutants, axonopathy and neurofilament accumulation in perikarya are features of two other murine lines with spontaneous mutations, targeted knockout mice, Tg4 transgenic mice carrying two deleted exons, mice with trapped actin-binding domain-containing isoforms, and conditional Schwann cell-specific knockout mice.
View Article and Find Full Text PDFElderberry diet enhances motor performance and reduces neuroinflammation-induced cell death in cerebellar ataxia rat models.
J Chem Neuroanat
April 2024
Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
Cerebellar ataxia (CA) is a condition in which cerebellar dysfunction results in movement disorders such as dysmetria, synergy and dysdiadochokinesia. This study investigates the therapeutic effects of elderberry (EB) diet on the 3-acetylpyridine-induced (3-AP) CA rat model. First, CA rat models were generated by 3-AP administration followed by elderberry diet treatment containing 2 % EB for 8 consecutive weeks.
View Article and Find Full Text PDFAccumulation Area of a Japanese P102L Variant Associated With Gerstmann-Sträussler-Scheinker Disease: The Ariake P102L Variant.
J Clin Neurol
May 2024
Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
Background And Purpose: The coast of Kyushu Island on Ariake Sea in Japan is known to be an accumulation area for patients with a proline-to-leucine substitution mutation at residue 102 (P102L) of the human prion protein gene (), which is associated with Gerstmann-Sträussler-Scheinker disease. We designated this geographical distribution as the "Ariake P102L variant." The purpose of this study was to characterize the clinical features of this variant.
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