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Inter-Laboratory Validation of Nodal/Paranodal Antibody Testing.
J Peripher Nerv Syst
March 2025
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Background And Aims: Reliable detection of antibodies against nodal targets is vital for the diagnosis of autoimmune nodopathies. The performance characteristics of recently developed in-house assays are unknown. We compared testing at four centres.
View Article and Find Full Text PDFEvaluation of fetal aortic isthmus diameter and flow in pregnant women with intrahepatic cholestasis of pregnancy; may it be a marker of poor perinatal outcomes?
J Obstet Gynaecol Res
February 2025
University of Health Sciences, Department of Obstetrics and Gynecology, Division of Perinatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
Aim: To evaluate the fetal aortic isthmus (AoI) diameter and flow in pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP).
Methods: In this prospective case-control study, fetal AoI diameter and Doppler measurements were performed in the ICP group (n: 30) and the control group (n: 42). Clinical characteristics, fetal AoI diameter and Doppler measurements, serum bile acid levels, liver enzyme levels, and obstetric and perinatal outcomes were compared between the groups.
Effect of Semen Collection in the Metabolite and Hormonal Content of Rabbit Seminal Plasma.
Vet Med Sci
March 2025
Department of Animal Production, Veterinary Faculty, Complutense University of Madrid, Madrid, Spain.
Blood serum (BS) and seminal plasma (SP) share a plethora of compounds that might present an individual and/or temporal concentration variation. We aimed to determine whether BS and SP concentrations of albumin, calcium, citrate, creatinine, fructose, glucose, lactate, total protein, urea, zinc, cortisol, anti-Müllerian hormone (AMH) and testosterone are related to weekly collections in New Zealand White (NZW) adult rabbit bucks. During a 12-week study, blood samples were obtained at the beginning and the end of the study period, and semen samples were taken twice a week from four NZW adult rabbit bucks, starting at 6-7 months of age.
View Article and Find Full Text PDFActivation of Local 11β-Hydroxysteroid Dehydrogenase Type 1 by Diosmetin Enhances Endogenous Glucocorticoid Levels to Alleviate Skin Inflammation: Insights Into a Novel Therapeutic Strategy for Atopic Dermatitis.
Exp Dermatol
February 2025
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Glucocorticoids (GCs) are synthesised de novo by peripheral tissues and the adrenal cortex of the hypothalamic-pituitary-adrenal axis. Skin expresses an enzyme called 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which reduces cortisone to the active hormone cortisol which activates GC receptors. 11β-HSD1 plays a significant role in alleviating atopic inflammation through the elevation of the concentrations of active GC in the skin.
View Article and Find Full Text PDFIdentification of a Novel ATP7A Variant in a Chinese Boy With Developmental Delay and Epilepsy.
Int J Dev Neurosci
February 2025
Department of Neurology, Women and Children's Hospital of Ningbo University, Ningbo, China.
Menkes disease (MD) is a rare X-linked recessive syndrome that is caused by mutations in the ATP7A gene, which encodes the P-type ATP enzyme. The ATP7A gene encodes 1500 amino acids and is expressed in a number of organs, including the brain, muscles, kidneys and lungs. ATP7A transports copper between cell membranes using energy generated by ATP hydrolysis.
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