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Phthalimides as anti-inflammatory agents.
Future Med Chem
January 2025
Department of Chemistry & Physics, Florida Gulf Coast University, Fort Myers, FL, USA.
Isoindoline-1,3-dione, also referred as phthalimide, has gained recognition as promising pharmacophore due to the documented biological activities of its derivatives. Phthalimides are a family of synthetic molecules that exhibit notable bioactivity across various fields, particularly as anticancer and anti-inflammatory agents. This review focuses on syntheses and anti-inflammatory studies of the reported phthalimide derivatives.
View Article and Find Full Text PDFPesticide pollution in India: Environmental and health risks, and policy challenges.
Toxicol Rep
December 2024
Institute of Environmental Studies, Kurukshetra University, Kurukshetra, Haryana 136119, India.
Intensive agriculture practices in India to meet the food demand of the increasing population have led to the use of agrochemicals such as pesticides in higher quantities to increase productivity resulting in contamination of the environment. Pesticides control pests, weeds, and diseases in plants, animals, and humans. Despite bans on pesticides such as organochlorides (OC), organophosphate (OP), or synthetic pyrethroids ranging from minimal to excessive, are detected in soil, surface water, and groundwater often exceeding WHO and BIS safety limits.
View Article and Find Full Text PDFPFAS Compounds PFOA and Gen X are Teratogenic to Sea Urchin Embryos.
bioRxiv
November 2024
Molecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston MA, USA.
Per-and polyfluorinated substances (PFAS) are synthetic chemicals that are used to make fluoropolymer coatings found in many products, such as non-stick pans, clothing, cosmetics, and food packaging. These highly persistent molecules are known as "forever chemicals" since they neither degrade environmentally nor break down enzymatically within biological systems. PFAS compounds readily contaminate water sources, and as a result, certain PFAS molecules have bioaccumulated in exposed species including humans.
View Article and Find Full Text PDFA Spectroscopic and In Silico Description of the Non-Covalent Interactions of Phthalic Acid Imide Derivatives with Deoxyribonucleic Acid-Insights into Their Binding Characteristics and Potential Applications.
Molecules
November 2024
Department of Basic Chemical Sciences, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556 Wrocław, Poland.
The treatment of cancer represents one of the most significant challenges currently facing modern medicine. The search for new drugs that are effective in the treatment of patients is an ongoing endeavor. It is frequently the case that the molecular target of anticancer drugs is a DNA molecule.
View Article and Find Full Text PDFTeratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature.
Radiol Case Rep
January 2025
University of Sousse, Faculty of Medicine of Sousse, Obstetrics and Gynecology Department, University Hospital Farhat Hached of Sousse, Tunisia.
Misoprostol, a synthetic analogue of prostaglandin E1, is commonly used in gynecology, particularly in combination with mifepristone for elective abortion. Although its use is widespread, the potential teratogenic effects of misoprostol in cases of failed medical abortion have not been sufficiently explored in the medical literature. Severe congenital malformations, although rare, have been reported, raising concerns about the impact of this drug on fetal development.
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