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Antibacterial Activity of Crude , , and Methanolic Extracts on serovar Manilae.
Acta Med Philipp
December 2024
Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila.
Background And Objective: Leptospirosis is a disease caused by pathogenic prevalent in tropical countries like the Philippines. Some studies have shown that the role of currently used antibiotics for leptospirosis is unclear since trials have found no significant benefit to patient outcomes compared to placebo. This signals the need for alternative therapies, such as herbal medicines, which may provide effective therapeutic regimens in treating this infection.
View Article and Find Full Text PDFEfficacy of Adjunct Hemoperfusion Compared to Standard Medical Therapy on 28-Day Mortality in Leptospirosis Patients with Renal Failure and Shock: A Single-Center Randomized Controlled Trial.
Trop Med Infect Dis
September 2024
Department of Adult Nephrology, National Kidney and Transplant Institute, Quezon City 1101, Philippines.
Hemoperfusion is a novel adjunct therapy that targets the dysregulated inflammatory events in severe sepsis. Previous studies have reported conflicting results on its efficacy and safety. This study was designed to assess the efficacy and safety of hemoperfusion among leptospirosis patients in septic shock and renal failure in terms of improvement in 28-day mortality, SOFA score, level of inflammatory markers, hemodynamics, and renal and pulmonary function.
View Article and Find Full Text PDFDetermination of Liver Function Tests and Liver Ultrasonographic Findings in Patients with Leptospirosis in a Tertiary Hospital.
Acta Med Philipp
March 2024
Division of Medical Oncology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila.
Article Synopsis
- Leptospirosis is a significant zoonotic disease prevalent in tropical areas, with severe cases presenting as Weil's syndrome, characterized by jaundice, kidney failure, and bleeding issues; yet, research on liver health in these patients is lacking in Asia.
- The study aims to analyze liver biochemical profiles and ultrasound findings in Filipino adults with confirmed leptospirosis and explore their relationship to severe illness outcomes and mortality.
- Findings revealed elevated bilirubin levels in leptospirosis patients, but only mild increases in liver enzymes; ultrasound results showed normal liver size and structure, while dyspnea was linked to a higher mortality risk.
Epidemiological anomaly detection in Philippine public health surveillance data through Newcomb-Benford analysis.
J Public Health (Oxf)
August 2024
Mathematics Division, University of Mindanao Digos College, Digos City 8002, Philippines.
Background: Public health surveillance is vital for monitoring and controlling disease spread. In the Philippines, an effective surveillance system is crucial for managing diverse infectious diseases. The Newcomb-Benford Law (NBL) is a statistical tool known for anomaly detection in various datasets, including those in public health.
View Article and Find Full Text PDFUnraveling the leptospirosis epidemic: tales from the Philippine outbreak - a short communication.
Ann Med Surg (Lond)
February 2024
St. Luke's aurora hospital, Milwaukee, Wisconsin.
Leptospirosis, also known as Weil's disease, is an emerging zoonotic infection that occurs worldwide but is particularly common in the tropics. There has been an increasing trend of leptospirosis in the Philippines since the outbreak occurred in 2020. The number of reported cases was 182 in 2020, 1661 in 2021, and 2794 in 2022.
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