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BACT: nonparametric Bayesian cell typing for single-cell spatial transcriptomics data.
Brief Bioinform
November 2024
Institute of Statistics and Big Data, Renmin University of China, No. 59 Zhongguancun Street, 100872 Beijing, China.
The spatial transcriptomics is a rapidly evolving biological technology that simultaneously measures the gene expression profiles and the spatial locations of spots. With progressive advances, current spatial transcriptomic techniques can achieve the cellular or even the subcellular resolution, making it possible to explore the fine-grained spatial pattern of cell types within one tissue section. However, most existing cell spatial clustering methods require a correct specification of the cell type number, which is hard to determine in the practical exploratory data analysis.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California, Irvine, Irvine, CA, USA.
Background: Alzheimer's disease (AD), characterized by tau lesions and amyloid plaques, has traditionally been investigated within the cortical domain. Recent neuroimaging studies have implicated micro- and macrostructural abnormalities in cortical layers during the progression of AD. While examinations from diverse brain regions have contributed to comprehending the regional severity, these approaches have constrained the ability to delineate cortical alterations in AD.
View Article and Find Full Text PDFAccuracy of Capillary Blood for Assessing Vitamin A Nutritional Status Among Children Under 7 Years of Age: A Multicenter Study.
Matern Child Nutr
January 2025
Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Vitamin A deficiency remains a major public health problem worldwide, particularly among young children. Capillary blood has the potential for application in vitamin A assessment. The aim of this study is to validate the accuracy of capillary blood for assessing vitamin A nutritional status among young children.
View Article and Find Full Text PDFFour-dimensional anatomical spinal reconstruction using pre-bent rods in thoracic adolescent idiopathic scoliosis.
Sci Rep
January 2025
Department of Orthopaedic Surgery, Hokkaido University Hospital, N15W7, Sapporo, Hokkaido, 060-8638, Japan.
A four-dimensional (4D) anatomical spinal reconstruction (ASR) technique and anatomical notch-free, pre-bent rods have been developed for thoracic adolescent idiopathic scoliosis (AIS) surgery. We aimed to evaluate the outcomes of ASR using notch-free rods through multiple comparisons with conventional methods, including the simultaneous double-rod rotation technique (SDRRT) and ASR using manually bent notched rods. Three consecutive series of 126 patients who underwent surgery for Lenke 1 AIS curves were prospectively followed up for 2 years after surgery.
View Article and Find Full Text PDFHyperspectral inversion of heavy metal content in farmland soil under conservation tillage of black soils.
Sci Rep
January 2025
College of Jilin Emergency Management, Changchun Institute of Technology, Changchun, 130012, China.
Globally, heavy metal (HM) soil pollution is becoming an increasingly serious concern. Heavy metals in soils pose significant environmental and health risks due to their persistence, toxicity, and potential for bioaccumulation. These metals often originate from anthropogenic activities such as industrial emissions, agricultural practices, and improper waste disposal.
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