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Reshaping Resistance: How Autovaccine Therapy Alters the Course of Recurrent Multidrug-Resistant Urinary Tract Infections.
Life (Basel)
January 2025
Urology Department, Hospital Universitari de Mollet, 08100 Barcelona, Spain.
Background/objectives: Urinary tract infections (UTIs) caused by multidrug-resistant (MDR) bacteria pose a considerable challenge due to high treatment failure rates and associated healthcare costs. This pioneering study evaluates the effectiveness of personalized autovaccine therapy in managing recurrent UTIs in patients with MDR bacteria, aiming to offer an innovative treatment that reduces antibiotic resistance and hospitalizations.
Methods: In this prospective, single-center study, 40 patients with recurrent MDR UTIs received personalized sublingual autovaccines derived from their own bacterial isolates.
Evaluating the use of Uromune autovaccine in recurrent urinary tract infections: a pilot unicenter retrospective study in Reus, Spain.
BMC Infect Dis
January 2025
Department of Urology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
Background: Urinary tract infections (UTIs) are a significant global health issue, especially among women, with growing concerns related to antibiotic resistance and adverse effects. The Uromune, a sublingual, heat-inactivated, polybacterial vaccine, represents a promising therapeutic alternative by enhancing immune responses against uropathogens.
Methods: This pilot retrospective study, conducted at Hospital Universitari de Sant Joan de Reus from January 2018 to August 2022, assessed the association between Uromune administration and changes in recurrent UTIs.
Evaluating the effectiveness of an autogenous vaccine to prevent motile Aeromonas septicaemia in striped catfish (Pangasianodon hypophthalmus) formulated by using DNA fingerprints for bacterial inclusion.
Fish Shellfish Immunol
December 2024
College of Aquaculture and Fisheries, Can Tho University, Viet Nam. Electronic address:
Many Aeromonas species are infecting striped catfish in the Mekong Delta in Vietnam. This study aimed to evaluate the effectiveness of autogenous vaccines developed by analysing the genetic diversity through DNA fingerprint analysis. A total of 38 Aeromonas strains isolated from 2017 to 2022 were analysed for phenotypic differences using the repetitive element sequence PCR (rep-PCR) with the (GTG) single-primer.
View Article and Find Full Text PDFInterleukin-17A (IL-17A) is involved in antibody specificity to conformational epitopes.
Biochem Biophys Res Commun
December 2024
Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina. Electronic address:
The specificity of antibodies (Ab) is essential for the precise recognition of foreign or dangerous molecules. We have shown that mice infected with non-pathogenic Lactate Dehydrogenase Elevating Virus (LDV) inoculated with human growth hormone (hGH) or Ovalbumin (OVA), exhibit modified specificity of anti-hGH or anti-OVA Ab associated with the secretion of IFN-γ, IL-13, and IL-17. Cytokines are directly or indirectly involved in the isotypes, specificity, and affinity of Ab.
View Article and Find Full Text PDFComparative safety and efficacy of autogenous vaccine administrated by different routes against furunculosis caused by Aeromonas salmonicida sub. salmonicida in large Rainbow trout (Oncorhynchus mykiss).
Fish Shellfish Immunol
September 2024
Oniris, INRAE, BIOEPAR, Nantes, France.
The development and growth of fish farming are hindered by viral and bacterial infectious diseases, which necessitate effective disease control measures. Furunculosis, primarily caused by Aeromonas salmonicida, stands out as a significant bacterial disease affecting salmonid fish farms, particularly rainbow trout. Vaccination has emerged as a crucial tool in combating this disease.
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