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CircRUNX1 enhances the Warburg effect and immune evasion in non-small cell lung cancer through the miR-145/HK2 pathway.
Cancer Lett
March 2025
Department of Thoracic Surgery, Affiliated Hospital 2 of Nantong University, Nantong First People's Hospital, Nantong 226001, China. Electronic address:
Non-small cell lung cancer (NSCLC) is acknowledged as the primary subtype of lung cancer. The Warburg effect, marked by elevated glucose consumption and lactate fermentation, is a prevalent characteristic of NSCLC. The mechanisms by which circRNA mediates the regulation of the Warburg effect and immune evasion in NSCLC remain unclear.
View Article and Find Full Text PDFExploring the Intricacies of Antimicrobial Resistance: Understanding Mechanisms, Overcoming Challenges, and Pioneering Innovative Solutions.
Eur J Pharmacol
March 2025
Department of Pharmacology, Shantou University Medical College, Shantou 515041, China. Electronic address:
Antimicrobial resistance (AMR) poses a growing global threat. This review examines AMR from diverse angles, tracing the story of antibiotic resistance from its origins to today's crisis. It explores the rise of AMR, from its historical roots to the urgent need to counter this escalating menace.
View Article and Find Full Text PDFThe spatial aggregation of phytophagous insects driven by the evolution of preference for plant chemicals.
J Theor Biol
March 2025
Department of Biological Sciences, Tokyo Metropolitan University, Tokyo 192-0364, Japan; Science Groove inc., Fukuoka, Japan.
Ecologists have shown considerable interest in the spatial patterns of organism distribution and the processes responsible for their formation and maintenance. The phytophagous insects typically use chemicals in plants as host-finding cues. Because nonvolatile chemicals remain near the source, the spatial structure of plant community determines the local distribution of insects.
View Article and Find Full Text PDFSpinel-based zinc-doped CoO (ZCO) catalytic membrane for efficient peroxymonosulfate activation and Chloroquine phosphate degradation: an atom doping strategy.
Environ Res
March 2025
School of Environmental Sciences and Engineering, Nanjing Tech University, Nanjing 211816, China.
The degradation of emerging contaminants (ECs) in wastewater remains a significant challenge, primarily due to the low activation efficiency and difficulty in catalyst recovery associated with traditional heterogeneous peroxymonosulfate (PMS) systems. In this study, a zinc (Zn)-doped CoO spinel (ZCO) catalyst was designed via an atom doping strategy and immobilized onto a polyvinylidene fluoride (PVDF) membrane to construct a ZCO@PVDF catalytic membrane, thereby developing an efficient and innovative approach for ECs degradation. The innovation of this study is the Zn doping-induced electron-polarized distribution, which creates electron-rich Co centers and significantly enhances the PMS activation efficiency.
View Article and Find Full Text PDFWhole-field mulching and removal indicated the flavonoid plasticity in marselan grapes and wines: Insights from the metabolome and transcriptome.
Plant Physiol Biochem
March 2025
Center for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China; Key Laboratory of Viticulture and Enology, Ministry of Agriculture and Rural Affairs, Beijing, 100083, China.
As an eco-friendly vineyard floor management, mulching can effectively control weeds, preserve soil moisture, reduce irrigation requirements, and modify the grapevine microclimate. However, its impact on the grapevine microclimate, as well as the variation in grape and wine flavonoids across different growth stages under mulching conditions remains insufficiently studied. Therefore, in the vineyard of a semi-arid region, the whole-field mulching (M) of black geotextile mulch was applied to Vitis vinifera Marselan grapevines from anthesis and removed at three phenological stages.
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