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N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference.
Brain
January 2025
Department of Psychiatry (UPK), University of Basel, 4001 Basel, Switzerland.
Perception integrates external sensory signals with internal predictions that reflect prior knowledge about the world. Previous research suggests that this integration is governed by slow alternations between an external mode, driven by sensory signals, and an internal mode, shaped by prior knowledge. Using a double-blind, placebo-controlled, cross-over experiment in healthy human participants, we investigated the effects of the N-Methyl-D-aspartate receptor (NMDAR) antagonist S-ketamine on the balance between external and internal modes.
View Article and Find Full Text PDFEffects of Acupuncture on Cognitive Functions in Patients with Relapsing-Remitting Multiple Sclerosis: A Randomized Controlled Trial.
Chin J Integr Med
January 2025
Department of Acupuncture and Moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100007, China.
Objective: To explore the effects of acupuncture in comparison with sham acupuncture on cognitive functions in patients with relapsing-remitting multiple sclerosis (RRMS).
Methods: In this randomized controlled trial, 31 RRMS patients in the acupuncture group were treated with traditional Chinese acupuncture based on the treatment principle of calming the mind, reinforcing qi and blood, and 31 patients in the control group were treated with sham acupuncture (shallow needling at non-acupuncture points) twice a week for 12 weeks. The primary outcome was the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) score, which was evaluated by a psychologist at baseline and after 12 weeks of treatment.
Paranoia, Functioning, and the Moderating Effect of Well-Being in a Community Sample of Adolescents.
J Adolesc
January 2025
Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA.
Introduction: Paranoid ideation is a relatively common experience in adolescence, yet it has not been well-explored in relation to psychological well-being and functioning in general population samples of youth. The current study aimed to investigate the relations between paranoia (operationalized as "persecutory ideation"), well-being, and two domains of functioning, social (e.g.
View Article and Find Full Text PDFTransient Psychotic Relapse Following COVID-19 in a Stable Schizophrenia Patient on Paliperidone Palmitate: A Case Report.
Cureus
November 2024
Psychiatry, Maudsley Health, Al Amal Psychiatric Hospital, Dubai, ARE.
Schizophrenia is a chronic psychiatric disorder marked by severe disturbances in thought, perception, and behavior. Long-acting injectable (LAI) antipsychotics, such as paliperidone, are widely used to promote sustained remission and ensure medication adherence, especially in patients prone to relapse. However, the COVID-19 pandemic has introduced unique challenges, with studies indicating that infections like COVID-19 may exacerbate psychiatric symptoms through neuroinflammatory pathways.
View Article and Find Full Text PDFPsychological symptoms and loneliness in unemployed people diagnosed with mental illnesses.
Soc Psychiatry Psychiatr Epidemiol
December 2024
Institute of Social Medicine, Occupational Health and Public Health, Leipzig University, Ph.- Rosenthal-Str. 55, 04103, Leipzig, Germany.
Purpose: Loneliness is a pervasive phenomenon that is linked to adverse health outcomes. Unemployed individuals with mental illnesses (UMIs) constitute a high-risk group, with substantial implications for both health and vocational (re)integration. This study aims to gain deeper insights into the relationships between psychological problems and symptoms of psychopathology and loneliness in UMIs.
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