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Insulinoma; a diagnostic challenge: a case report.
J Pak Med Assoc
January 2025
Department of Endocrinology, Shaukat Khanum Cancer Memorial Hospital and Research Centre, Lahore, Pakistan.
Insulinoma is a pancreatic neuroendocrine tumour that primarily leads to episodes of hypoglycaemia due to inappropriate and excessive secretion of insulin. It classically presents with neuroglycopenic and autonomic sympathetic symptoms, which resolve promptly with glucose administration. Elevated level of insulin and Cpeptide in the presence of low plasma glucose level and absence of plasma sulfonylurea are diagnostic features.
View Article and Find Full Text PDFGlycogen Storage Disease Type Ia: A Retrospective Claims Analysis of Complications, Resource Utilization, and Cost of Care.
J Health Econ Outcomes Res
January 2025
Ultragenyx Pharmaceutical Inc., Novato, CA, USA.
Glycogen storage disease type Ia (GSDIa) is a rare inherited disorder resulting in potentially life-threatening hypoglycemia, metabolic abnormalities, and complications often requiring hospitalization. This retrospective database analysis assessed the complications, resource utilization, and costs in a large cohort of patients with GSDIa. We conducted a retrospective cohort study of GSDIa patients and matched non-GSDIa comparators utilizing the PharMetrics® Plus database.
View Article and Find Full Text PDF[Review of Multiple Endocrine Neoplasia Type 1 Based on a Clinical Case].
Rev Med Chil
June 2024
Departamento de endocrinología, Hospital Clínico San Borja Arriarán, Santiago, Chile.
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disease with an estimated prevalence of 2 per 100,000. This disease is caused by a mutation in the tumor suppressor gene MEN1, which is located on chromosome 11 and codifies the menin protein. It is characterized by a predisposition of parathyroids, enteropancreatic, and anterior pituitary tumors, affecting the quality of life and lifespan of those who have the disease.
View Article and Find Full Text PDFRobotic-assisted pancreatic enucleation: Posterior uncinate approach.
Updates Surg
December 2024
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Article Synopsis
- - Functional pancreatic neuroendocrine tumors (pNET) require surgical removal, with enucleation being the top choice for small, well-differentiated tumors under 2 cm.
- - Insulinomas, a type of pNET, are ideal candidates for enucleation, but surgeries involving the uncinate process of the pancreas can be complex.
- - A video demonstrates a successful robotic-assisted enucleation of an insulinoma in a 41-year-old man, resulting in symptom relief and low post-operative complications.
Glucagon-Like Peptide-1 Receptor-Targeted PET/CT With 68 Ga-HBED-CC-Exendin-4 in Localizing Insulinoma : A Head-to-Head Comparison to 68 Ga-NOTA-Exendin-4.
Clin Nucl Med
January 2025
From the Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Article Synopsis
- A study was conducted to compare a new GLP-1R-targeted PET agent, 68 Ga-HBED-CC-exendin-4, with an older version, 68 Ga-NOTA-exendin-4, for locating insulinoma in patients with hyperinsulinemic hypoglycemia.
- Both agents demonstrated 100% sensitivity, but 68 Ga-HBED-CC-exendin-4 had a lower tumor uptake value compared to 68 Ga-NOTA-exendin-4, although both maintained similar tumor-to-background ratios.
- The new agent also showed a significant reduction in renal accumulation, potentially enhancing the detection of tumors located near the kidney.
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