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Fluorous-Phase- and Chiral-Axis-Enhanced Fluorescent Sensitivity and Chemoselectivity for Cysteine Recognition.
Org Lett
January 2025
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Highly fluorinated naphthyl aldehyde and binaphthyl aldehyde ()- were designed and synthesized for fluorous-phase-based sensing. Greatly enhanced sensitivity and chemoselectivity in going from to ()- in the fluorescent detection of cysteine has been discovered. This is attributed to the increased structural rigidity of the axially chiral binaphthyl unit in ()- upon reaction with cysteine to form the corresponding thiazolidine product.
View Article and Find Full Text PDFChemical O-ADP-Ribosylations: Synthesis and Bioconjugation of ADPr-Peptides/Proteins from NAD.
Angew Chem Int Ed Engl
January 2025
Henan Normal University School of Chemistry and Chemical Engineering, Chemistry, CHINA.
ADP-ribosylation is a complex post-translational modification involved in key physiological processes and associated with various health and disease states. The growing interest in ADP-ribosylation necessitates straightforward and efficient synthetic methods for the preparation of ADP-ribosylated peptides/proteins. In this study, we report a facile reaction between nicotinamide adenine dinucleotide (NAD+) and alcohols promoted by a combination of ionic liquids, yielding up to 94% with α:β ratios ranging from 88:12 to 99:1 and a switchable configuration selectivity.
View Article and Find Full Text PDFPreparation of pH-resistant multicolor thiol fluorescent carbon dot using cysteine and neutral red as precursors and its application in detection and adsorption of apigenin.
Talanta
January 2025
College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China. Electronic address:
Conventional carbon dots (CDs) typically exhibit substantial variations in fluorescence intensity across different pH. This limitation underscores the pressing need for advancements in their stability and performance under diverse environmental conditions. Herein, l-cysteine and neutral red are selected as precursors, and three kinds of CDs, which can emit red, orange, and green fluorescent light (assigned as r-CD, o-CD, g-CD, respectively), are synthesized by simply changing the reaction conditions.
View Article and Find Full Text PDFNitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging.
Nat Commun
January 2025
State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Bioorthogonal chemistry-mediated self-assembly holds great promise for dynamic molecular imaging in living organisms. However, existing approaches are limited to nanoaggregates with 'always-on' signals, suffering from high signal-to-background ratio (SBR) and compromised detection sensitivity. Herein we report a nitrile-aminothiol (NAT) bioorthogonal fluorogenic probe (CyNA-SS-FK) for ultrasensitive diagnosis of orthotopic hepatocellular carcinoma.
View Article and Find Full Text PDFAn electrochemiluminescence biosensor based on silver-cysteine nanorod as an emitter and AgNP-decorated FeMoO as a signal amplifier for sensitive detection of heart-type fatty acid binding protein.
Mikrochim Acta
December 2024
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China.
An electrochemiluminescence (ECL) immunosensor was developed for the highly sensitive and specific detection of heart-type fatty acid binding protein (H-FABP) and the rapid diagnosis of acute myocardial infarction (AMI). H-FABP is a biomarker that is highly specific to cardiac tissue and is associated with a range of cardiac diseases. Following myocardial injury, the rate of increase in H-FABP levels is greater than that observed for myoglobin and troponin.
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