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Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.
Cell Signal
January 2025
Clinic School of Medicine and Affiliated Hospital, North China University of Science and Technology, Tangshan, China. Electronic address:
Purpose: This study aims to investigate whether zinc ion (Zn) alleviates myocardial ischemia-reperfusion injury (MIRI) through the MAM-associated signaling pathway and to explore its impact on ERS and calcium overload.
Methods: H9C2 cells were cultured in a DMEM supplemented with 10 % fetal bovine serum and 1 % antibiotic solution. A MIRI model was established through simulated ischemia and reoxygenation with Zn treatment in a complete medium.
The Wilms' Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair.
Cells
December 2024
Université Côte d'Azur, CNRS, INSERM, iBV, 06107 Nice, France.
The Wilms' tumor suppressor WT1 is essential for the development of the heart, among other organs such as the kidneys and gonads. The Wt1 gene encodes a zinc finger transcription factor that regulates proliferation, cellular differentiation processes, and apoptosis. WT1 is also involved in cardiac homeostasis and repair.
View Article and Find Full Text PDFLoss of GATAD1 in cardiomyocyte does not cause cardiomyopathy in mice.
J Mol Histol
December 2024
Department of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA.
GATA zinc finger domain containing 1 (GATAD1) is an as-yet uncharacterized zinc finger domain protein, which was initially identified as a histone 3 trimethylated at lysine 4 (H3K4me3) interactor. A recessive mutation in GATAD1 is associated with adult-onset dilated cardiomyopathy and heart failure, suggesting that GATAD1 is critical for maintaining normal cardiac structure and function. However, little is known as to the specific role of GATAD1 in cardiomyocytes.
View Article and Find Full Text PDFRecent Progress in Myocardial Perfusion Imaging Techniques.
Nucl Med Mol Imaging
December 2024
Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Article Synopsis
- Nuclear cardiology has advanced rapidly, particularly in myocardial perfusion imaging (MPI) since the 1970s, which is vital for assessing and managing coronary artery disease.
- Recent innovations include the development of gamma cameras with cadmium zinc telluride (CZT) systems and enhancements in software, as well as ongoing studies into new radiopharmaceuticals for positron emission tomography (PET)-MPI.
- Despite these advancements, challenges like high equipment and examination costs, along with limited accessibility, pose significant barriers to the practical use of these technologies in nuclear medicine.
GATAD1 is involved in sphingosylphosphorylcholine-attenuated myocardial ischemia-reperfusion injury by modulating myocardial fatty acid oxidation and glucose oxidation.
Free Radic Biol Med
February 2025
Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, 266237, China. Electronic address:
Article Synopsis
- Modulating the balance between glucose and fatty acid metabolism is a promising therapy for myocardial ischemia/reperfusion (I/R) injury, with Sphingosylphosphorylcholine (SPC) showing cardioprotective effects during heart attacks by influencing various transcription factors.* -
- The study found that knocking out the GATA zinc finger domain protein 1 (GATAD1) in heart tissue led to increased heart damage and reduced the protective impact of SPC in I/R mice, indicating GATAD1's role in cardiac health.* -
- GATAD1 regulates the expression of genes related to fatty acid oxidation and glucose oxidation, suggesting that SPC might prevent I/R injury by shifting metabolism in favor
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