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Mild Gestational Hypothyroidism in Mice Has Transient Developmental Effects and Long-Term Consequences on Neuroendocrine Systems.
Thyroid
January 2025
National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Thyroid hormones (TH) play a key role in fetal brain development. While severe thyroid dysfunction, has been shown to cause neurodevelopmental and reproductive disorders, the rising levels of TH-disruptors in the environment in the past few decades have increased the need to assess effects of subclinical (mild) TH insufficiency during gestation. Since embryos do not produce their own TH before mid-gestation, early development processes rely on maternal production.
View Article and Find Full Text PDFA transient neurohormonal circuit controls hatching in fish.
Science
December 2024
Department of Aquaculture and Poultry, Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Rishon Letziyon, Israel.
Article Synopsis
- Hatching is a crucial event for egg-laying species, timed to enhance survival during early life stages.
- Researchers discovered that thyrotropin-releasing hormone (Trh) triggers hatching in zebrafish by creating a temporary circuit that delivers the hormone into the embryo's bloodstream.
- The study also found that Trh stimulates hatching in a related fish species, highlighting a long-evolved neuroendocrine mechanism controlling this important life event in oviparous fish.
A neuroendocrine circuit controls when fish larvae are ready to hatch.
View Article and Find Full Text PDFUnveiling putative modulators of mutable collagenous tissue in the brittle star Ophiomastix wendtii: an RNA-Seq analysis.
BMC Genomics
October 2024
Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, 9331 Robert D. Snyder Rd., Charlotte, 28223, NC, USA.
Collagenous connective tissue, found throughout the bodies of metazoans, plays a crucial role in maintaining structural integrity. This versatile tissue has the potential for numerous biomedical applications, including the development of innovative collagen-based biomaterials. Inspiration for such advancements can be drawn from echinoderms, a group of marine invertebrates that includes sea stars, sea cucumbers, brittle stars, sea urchins, and sea lilies.
View Article and Find Full Text PDFIdentification and expression profiling of neuropeptides and neuropeptide receptor genes in a natural enemy, .
Front Physiol
October 2024
College of Horticulture and Landscape Architecture, Tianjin Agricultural University, Tianjin, China.
Introduction: Neuropeptides and their receptors constitute diverse and abundant signal molecules in insects, primarily synthesized and released primarily from neurosecretory cells within the central nervous system Neuropeptides act as neurohormones and euromodulators, regulating insect behavior, lifecycle, and physiology by binding to receptors on cell surface. As a typical natural predator of agricultural pests, the lady beetle, , has been commercially mass-cultured and widely employed in pest management. Insect diapause is a physiological and ecological adaptative strategy acquired in adverse environments.
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