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Utilization of mannan oligosaccharides as antibiotic substitutes in laying hens.
Vet Res Forum
December 2024
Department of Animal Production, Faculty of Veterinary Medicine and Animal Science, Universidad Cooperativa de Colombia, Ibague, Colombia.
Among global concerns about antibiotic resistance, it is necessary to identify food-safe alternatives to enhance production. This study aimed to evaluate the impact of mannan oligosaccharides (MOS) inclusion to replace antibiotic growth promoters (AGP) in the diets of ISA Brown laying hens aged between 23 and 31 weeks. Two hundred forty hens were grouped into five treatments: Control, AGP (130 ppm of enramycin 8.
View Article and Find Full Text PDFIntestinal barrier function, caecal microbiota and growth performance of thermoneutral or heat stressed broiler chickens fed reduced crude protein diets supplemented with guanidinoacetic acid.
Poult Sci
January 2025
Feedworks Pty Ltd, Romsey, VIC, Australia.
The effectiveness of guanidinoacetic acid (GAA) in reduced protein (RP) diets on performance and gut health of broilers under heat stress is largely unknown. A 35-d experiment was conducted using four dietary treatments: a standard protein diet (SP, 22.1 and 20.
View Article and Find Full Text PDFSupplemental glucose oxidase as an antibiotic substitute alleviates diarrhea and improves intestinal health in weaned piglets.
Vet Q
December 2025
Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Weaning stress-induced diarrhea is a serious issue in pig production. This study aimed to evaluate the potential of glucose oxidase (GOD) as an antibiotic substitute to alleviate diarrhea and improve gut health in weaned piglets. According to a randomized complete block design, 250 piglets weaned around 21 d of age were allocated into 5 groups (5 replicates/group), which received a basal diet without or with supplemental 200 mg/kg antibiotic, 500, 1000 and 2000 U/kg GOD, respectively.
View Article and Find Full Text PDFThe gastrointestinal absorption characteristics and metabolic mechanisms of polysaccharides from Hohenbuehelia serotina.
Food Chem
March 2025
Nano-Biotechnology Key Laboratory of Hebei Province, State Key Laboratory of Metastable Materials Science and Technology, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, PR China. Electronic address:
In order to elucidate the digestion, absorption and metabolism mechanism, Hohenbuehelia serotina polysaccharides were successfully labelled by fluorescein isothiocyanate (FITC-Tyr-HSP), with the fluorescent substitution degree of 0.37 %. FITC-Tyr-HSP with excellent physiological stability possessed the significant fluorescent characteristics, which could be dynamically monitored by in vivo fluorescence imaging and high performance gel permeation chromatography-fluorescence detector (HPGPC-FLD).
View Article and Find Full Text PDFThe genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study.
Lancet Oncol
January 2025
Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Faculty of Health, Medicine, and Social Care, Anglia Ruskin University, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge, UK. Electronic address:
Background: Procarbazine-containing chemotherapy regimens are associated with cytopenias and infertility, suggesting stem-cell toxicity. When treating Hodgkin lymphoma, procarbazine in escalated-dose bleomycin-etoposide-doxorubicin-cyclophosphamide-vincristine-procarbazine-prednisolone (eBEACOPP) is increasingly replaced with dacarbazine (eBEACOPDac) to reduce toxicity. We aimed to investigate the impact of this drug substitution on the mutation burden in stem cells, patient survival, and toxicity.
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