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Erythrocyte indices and response to hypoxia-inducible factor prolyl hydroxylase inhibitors in chronic kidney disease patients with renal anemia: a retrospective study.
BMC Nephrol
November 2024
Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Background: Although erythropoiesis-stimulating agents (ESAs) have been the standard treatment for renal anemia, ESA hyporesponsiveness remains a concern. Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of agents indicated for renal anemia. Several lines of evidence indicate that HIF-PHIs affect erythrocyte indices; nonetheless, their clinical significance remains unclear.
View Article and Find Full Text PDFTolerability and first hints for potential efficacy of motor-cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint.
Neuroprotection
September 2024
Clinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, City Campus, Göttingen, Germany.
Article Synopsis
- Hypoxia is increasingly recognized as a key factor that helps brain cells adapt to low oxygen levels and reduced metabolism, leading to what the authors call "functional hypoxia."
- The study investigates the effects of combined mild inspiratory and functional hypoxia during motor-cognitive training in a group of 20 participants, including healthy individuals and those with depression or autism spectrum disorder.
- Initial findings suggest that this training under low oxygen conditions is well-tolerated and may improve well-being, cognitive performance, physical fitness, and affect immune cell responses, warranting further research with a controlled trial to better assess the benefits.
Structural and functional characterization of haemoglobin genes in Labeo catla: Insights into hypoxic adaptation and survival.
Int J Biol Macromol
November 2024
ICAR- Directorate of Coldwater Fisheries and Research, Bhimtal, Uttarakhand, India. Electronic address:
Article Synopsis
- - The study focused on the haemoglobin protein structure in Labeo catla, highlighting the encoding of its subunits (α and β) by HBA and HBB genes, which were sequenced to get their complete coding sequences.
- - Phylogenetic analysis indicated that Labeo catla is closely related to other cyprinid fish, particularly Labeo rohita, and bioinformatics tools were used to predict gene function and protein structure.
- - Under hypoxic conditions, both HBA and HBB genes were found to be significantly upregulated, leading to increased haematological indices; however, a subsequent decrease in their expression resulted in higher mortality rates among the fish.
Evaluation of the effect of voxelotor and darbepoetin alfa on hemoglobin levels in patients with sickle cell disease.
Expert Rev Hematol
June 2024
Clinical & Administrative Pharmacy Sciences, Howard University College of Pharmacy, Washington, DC, USA.
Background: To date, there is limited evidence on patients utilizing both voxelotor and darbepoetin alfa and its impact on hemoglobin levels. The objective is to evaluate the effect of voxelotor and darbepoetin alfa on hemoglobin levels in patients with SCD.
Research Design And Methods: This was a retrospective chart review study that assessed the primary independent variable as the utilization of either voxelotor alone, darbepoetin alfa alone, or the concurrent administration of voxelotor and darbepoetin alfa.
Background: Impaired kidney function is frequently observed in patients following cardiopulmonary bypass (CPB). Our group has previously linked blood transfusion to acute declines in S-nitroso haemoglobin (SNO-Hb; the main regulator of tissue oxygen delivery), reductions in intraoperative renal blood flow, and postoperative kidney dysfunction. While not all CPB patients receive blood, kidney injury is still common.
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