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Effects of Replacing Inorganic Sources of Copper, Manganese, and Zinc with Different Organic Forms on Mineral Status, Immune Biomarkers, and Lameness of Lactating Cows.
Animals (Basel)
January 2025
Sino-US Joint Lab on Nutrition and Metabolism of Ruminant, Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
(Objectives) The objectives of this study were to evaluate the effect of half-replacement of the supplementary sulfate sources of Cu, Mn, and Zn with methionine-hydroxy-analog-chelated (MHAC) mineral or amino-acid-complexed (AAC) mineral forms in diets on the mineral status, blood immune biomarkers, and lameness of lactating cows. (Methods) Sixty multiparous Holstein cows (158 ± 26 days in milk; body weight: 665 ± 52 kg; milk yield: 32 ± 7 kg/day) were randomly assigned into one of three dietary treatments ( = 20 per group): (1) MHAC: 50% replacement of sulfate minerals with MHAC forms. (2) AAC: 50% replacement of sulfate minerals with AAC forms.
View Article and Find Full Text PDFDysfunctional copper homeostasis in affects genomic and neuronal stability.
Redox Biochem Chem
December 2024
Food Chemistry with Focus on Toxicology, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Germany.
While copper (Cu) is an essential trace element for biological systems due to its redox properties, excess levels may lead to adverse effects partly due to overproduction of reactive species. Thus, a tightly regulated Cu homeostasis is crucial for health. Cu dyshomeostasis and elevated labile Cu levels are associated with oxidative stress and neurodegenerative disorders, but the underlying mechanisms have yet to be fully characterized.
View Article and Find Full Text PDFPrecise and panoramic study on the nutritional components of specific milk of goats and sheep.
Food Chem
February 2025
College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. Electronic address:
Article Synopsis
- - The study examined the milks of humans, goats, sheep, and pigs using advanced techniques like metabolomics, lipidomics, and proteomics to find differences among them and similarities to human milk for infant formula development.
- - Key findings revealed that goat milk had high levels of lactoperoxidase, inosine, and allantoin, while sheep milk showed higher concentrations of ceruloplasmin and alpha-ketoglutarate.
- - Additionally, both goat and sheep milks had a relatively high amount of linoleic acid (LA), and pig milk was noted for having significant levels of milk fat globule EGF factor 8 protein.
The primary studies of epigallocatechin-3-gallate in improving brain injury induced by chronic high-altitude natural environment in rats by 7.0T high-field MR imaging.
Arch Biochem Biophys
February 2025
Department of Radiology, West China Hospital, Sichuan University, Chengdu, PR China; Molecular Imaging Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China. Electronic address:
Background: Epigallocatechin-3-gallate (EGCG) is one of the most abundant and important bioactive polyphenolic compounds in green tea. However, despite its potent antioxidant effects, its neuroprotective effects on chronic high altitude (HA)-induced nerve damage have not been reported. The purpose of this study is to use quantitative susceptibility mapping (QSM) with pathology to dynamically evaluate the status of brain damage and the effect of EGCG.
View Article and Find Full Text PDFExtracellular vesicles and citrullination signatures are novel biomarkers in sturgeon (Acipenser gueldenstaedtii) during chronic stress due to seasonal temperature challenge.
Fish Shellfish Immunol
November 2024
Pathobiology and Extracellular Vesicles Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK. Electronic address:
Acipenser gueldenstaedtii is one of the most cultured sturgeon species worldwide and of considerable economic value for caviar production. There are though considerable challenges around chronic stress responses due to increased summer temperatures, impacting sturgeons' immune responses and their susceptibility to opportunistic infections. The identification of molecular and cellular pathways involved in stress responses may contribute to identifying novel biomarkers reflective of fish health status, crucial for successful sturgeon aquaculture.
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