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Effect of the combination of methyltestosterone and esterified estrogens compared with esterified estrogens alone on apolipoprotein CIII and other apolipoproteins in very low density, low density, and high density lipoproteins in surgically postmenopausal women.
J Clin Endocrinol Metab
May 2004
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Androgens are known to lower plasma triglycerides, an independent risk factor for coronary heart disease (CHD). Triglycerides are carried in plasma on very low density (VLDL) and low density (LDL) lipoprotein particles. Apolipoprotein CIII (apoCIII), a strong predictor of CHD, impairs the metabolism of VLDL and LDL, contributing to increased triglycerides.
View Article and Find Full Text PDFEffects of dehydroepiandrosterone on rat apolipoprotein AI gene expression in the human hepatoma cell line, HepG2.
Metabolism
March 2002
Division of Endocrinology, Diabetes, and Metabolism, Saint Louis University School of Medicine, St Louis, MO 63104, USA.
Serum apolipoprotein AI (apoAI) levels correlate with the risk of developing atherosclerosis. Previous studies have suggested that dehydroepiandrosterone (DHEA) lowers high-density lipoprotein (HDL)-cholesterol levels. We investigated whether or not DHEA may lower HDL-cholesterol levels by suppressing apoAI gene transcription in hepatocytes.
View Article and Find Full Text PDFObjective: To compare an oral estrogen-androgen combination with estrogens alone on bone, menopausal symptoms, and lipoprotein profiles in postmenopausal women.
Methods: Surgically menopausal women received oral esterified estrogens (1.25 mg), or esterified estrogens (1.
Objective: To compare the efficacy and safety of esterified estrogens with and without methyltestosterone.
Methods: Twenty-six women participated in a double-blind randomized trial for 6 months. Outcome measures included serum total and lipoprotein-bound cholesterol, vasomotor symptoms, vaginal cytology and endometrial histology, and chemistry values.
Lipid metabolism in young males with hypotestosteronaemia and oligospermia prior to, during, and after treatment.
Int Urol Nephrol
December 1991
Institute of Experimental Endocrinology, Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava.
Relationships between plasma testosterone levels and selected parameters of lipid metabolism were studied in a group of young sterile males prior to, during, and after hormone therapy. Initial hypertriacylglycerolaemia and decreased concentrations of HDL cholesterol returned to normal values after 30 days of methyltestosterone administration. LDL cholesterol concentrations decreased significantly as did plasma apolipoprotein B levels.
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