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Cyclic Peptide MV6, an Aminoglycoside Efficacy Enhancer Against .
Antibiotics (Basel)
December 2024
Barcelona Institute for Global Health (ISGlobal), 08036 Barcelona, Spain.
: is a globally emerging pathogen with widespread antimicrobial resistance driven by multiple mechanisms, such as altered expression of efflux pumps like AdeABC, placing it as a priority for research. Driven by the lack of new treatments, alternative approaches are being explored to combat its infections, among which efficacy-enhancing adjuvants can be found. This study presents and characterizes MV6, a synthetic cyclic peptide that boosts aminoglycoside efficacy.
View Article and Find Full Text PDFCombination Effect of Phenylalanine-Arginine-Beta-Naphthylamide and Curcumin on the Expression of the Gene in Aminoglycoside-Resistant Clinical Isolates of .
Health Sci Rep
December 2024
Molecular and Cell Biology Research Centre, Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran.
Background And Aims: Overexpression of MexXY-OprM efflux pump causes resistance to aminoglycosides in . We aimed to investigate the relationship between resistance to aminoglycosides and the MexXY-OprM expression level in clinical isolates without and after treatment with curcumin and/or phenylalanine-arginine-beta-naphthylamide (PAβN) as the efflux pump inhibitors.
Methods: We collected 100 clinical isolates from hospitalized patients.
Colistin Insusceptibility in Carbapenem-Resistant Enterobacteriaceae Isolates From a Tertiary Referral Centre.
Cureus
October 2024
Department of Microbiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth, Satara, IND.
Article Synopsis
- * A study conducted over two years at Krishna Hospital in India analyzed 82 carbapenem-resistant isolates, revealing a significant prevalence of resistance, particularly among men aged 51-60, predominantly from urine samples in the Intensive Care Unit.
- * Results showed an alarming 18.7% colistin resistance among CRE isolates, with the most effective alternatives being aminoglycosides like amikacin despite many isolates showing antibiotic resistance.
Enhanced Production of Sisomicin in Micromonospora inyoensis by Protoplast Mutagenesis and Fermentation Optimization.
Appl Biochem Biotechnol
September 2024
Laboratory of Pharmaceutical Engineering, School of Life Science and Health Engineering, Jiangnan University, Wuxi, 214122, China.
Sisomicin is a broad-spectrum aminoglycoside antibiotic and is the precursor of netilmicin and plazomicin. However, the fermentation level of sisomicin is still low compared with other antibiotics, which restricts the application of sisomicin and its derivatives. In this study, to improve sisomicin production, breeding of high-yielding sisomicin strains was conducted with chemical mutagenesis using Micromonospora inyoensis OG-1 (titer, 1042 U·mL) as the starting strain.
View Article and Find Full Text PDFImproved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics.
Antimicrob Agents Chemother
February 2024
Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Article Synopsis
- Aminoglycosides are effective for treating serious lung infections, but detailed studies on how well they penetrate lung fluid are limited.
- The research analyzed data from eight studies and found that aminoglycoside penetration into lung fluid varies, with ELF concentrations ranging from 50% to 100% of those in plasma.
- While the peak concentrations of aminoglycosides in lung epithelial lining fluid were lower than expected, their overall exposure remained moderately high, indicating a complex relationship between the drug and lung tissue.
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