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Characteristics of Tylvalosin Tartrate Enteric Amorphous Pellets Prepared by Liquid Layering.
Pharm Res
January 2025
Department of Pharmaceutics Science, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Purpose: Tylvalosin Tartrate (TAT), a new-generation macrolide antibiotic, undergoes significant degradation in the stomach and in vivo rapid elimination upon oral administration, resulting in poor bioavailability. This study developed TAT enteric amorphous pellets by liquid layering (TAT/EAP-LL) with pH-sensitive and burst release characteristics, to enhance drug stability in the stomach and concentration enrichment in the duodenum.
Methods: The drug loading layer, isolation layer and enteric layer were formed on the surface of the blank core pellets.
Duodenogastric Reflux in Health and Disease: Insights from a Computational Fluid Dynamics Model of the Stomach.
Am J Physiol Gastrointest Liver Physiol
January 2025
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
The stomach is responsible for physically and chemically processing the ingested meal before controlled emptying into the duodenum through the pyloric sphincter. An incompetent pylorus allows reflux from the duodenum back into the stomach, and if the amount of reflux is large enough, it could alter the low pH environment of the stomach and erode the mucosal lining of the lumen. In some cases, the regurgitated contents can also reach the esophagus leading to additional complications.
View Article and Find Full Text PDF[Gastrointestinal hamartomatous inverted hyperplastic polyps: a clinicopathological analysis of ten cases].
Zhonghua Bing Li Xue Za Zhi
February 2025
Department of Pathology, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.
To investigate the clinicopathological features, diagnosis, genetic alterations, and biological behaviors of hamartomatous inverted hyperplastic polyp (HIHP) in the gastrointestinal tract. The clinical, sonographic, endoscopic and pathologic data of 10 HIHP cases diagnosed at the First Affiliated Hospital of Air Force Medical University, Xi'an, China from January 2013 to March 2024 were collected. Their clinicopathological features and histological morphology were analyzed.
View Article and Find Full Text PDFBouveret's Syndrome as a Rare Life-Threatening Complication of Gallstone Disease-A Surgical Problem: Two Case Reports.
Medicina (Kaunas)
December 2024
Medical Faculty, University of Nis, 18000 Nis, Serbia.
: Bouveret syndrome, a rare and often underdiagnosed variant of gallstone ileus, is characterized by the presence of a large gallstone impacted in the proximal duodenum, resulting in significant gastric outlet obstruction and aerobilia. Early identification of Bouveret syndrome is crucial for developing an appropriate surgical strategy. : A 76-year-old female underwent a contrast-enhanced abdominal CT scan, which revealed a cholecysto-duodenal fistula with a 3.
View Article and Find Full Text PDFInternational Validation of a Novel PEACE Scale to Improve the Quality of Upper Gastrointestinal Mucosal Inspection During Endoscopy.
Clin Transl Gastroenterol
January 2025
Division of Gastroenterology, Kansas City VA Medical Center, Kansas City, Missouri, USA.
Introduction: The performance of a high quality esophagogastroduodenoscopy (EGD) is dependent on the mucosal cleanliness. Recently, the Polprep: Effective Assessment of Cleanliness in EGD (PEACE) scale was created to assess the degree of mucosal cleanliness during EGD. The aim of this study was to validate this scoring system in a cohort of international endoscopists.
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