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Pregnancy Outcomes and Maternal Periodontal Diseases: The Unexplored Connection.
Cureus
June 2024
Department of Periodontology, Bharati Vidyapeeth (Deemed to be University), Pune, IND.
In the early 20th century, numerous in-vitro studies, animal studies, epidemiological studies, and human trials have attempted to demonstrate the interrelationship between pregnancy outcomes and maternal periodontal disease. This review aims to shed light on the unexplored connections between pregnancy outcomes and maternal periodontal diseases. A literature search was conducted using electronic databases such as PubMed, Scopus, Google Scholar, Web of Science, and Embase.
View Article and Find Full Text PDFMaternal 129S1/SvImJ background attenuates the placental phenotypes induced by chronic paternal alcohol exposure.
Reprod Toxicol
June 2024
Department of Veterinary Physiology & Pharmacology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. Electronic address:
Paternal alcohol use is emerging as a plausible driver of alcohol-related growth and patterning defects. Studies from our lab using an inbred C57Bl/6 J mouse model suggest that these paternally-inherited phenotypes result from paternally programmed deficits in the formation and function of the placenta. The 129S1/SvImJ genetic background is typically more susceptible to fetoplacental growth defects due to strain-specific differences in placental morphology.
View Article and Find Full Text PDFThe clinical value of optical genome mapping in the rapid characterization of RB1 duplication and 15q23q24.2 triplication, for more appropriate prenatal genetic counselling.
Mol Genet Genomic Med
April 2024
Genetics Department, CHI de Poissy-St Germain en Laye, Poissy, France.
Background: Despite recent advances in prenatal genetic diagnosis, medical geneticists still face considerable difficulty in interpreting the clinical outcome of copy-number-variant duplications and defining the mechanisms underlying the formation of certain chromosomal rearrangements. Optical genome mapping (OGM) is an emerging cytogenomic tool with proved ability to identify the full spectrum of cytogenetic aberrations.
Methods: Here, we report on the use of OGM in a prenatal diagnosis setting.
SHFM (Split Hand/Foot Malformation) is a heterogeneous group of disorders characterized by the presence of clefts in the hands and feet, along with syndactyly of the digits. In this article, we describe a family in which two members exhibit characteristic developmental abnormalities associated with SHFM, presenting with variable clinical features. Using whole-genome sequencing, we identified a microduplication of a chromosomal segment on locus 10q24.
View Article and Find Full Text PDFPositive reappraisal coping mediates the relationship between parental abuse and lack of affection on adulthood generalized anxiety severity.
J Anxiety Disord
March 2024
Department of Psychology, The Pennsylvania State University, USA.
Article Synopsis
- Childhood abuse and lack of parental affection increase the risk of developing anxiety disorders in adulthood, with positive reappraisal coping identified as a potential mediating factor.* -
- The study utilized data from 3,294 participants over multiple time points to analyze how childhood experiences influence adult generalized anxiety disorder (GAD) symptoms.* -
- Results show that positive reappraisal coping helps explain the relationship between maternal abuse and GAD severity, indicating that positive coping strategies can mitigate some negative effects of harsh childhood experiences.*
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