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Study Design: Prospective trial comparing the investigation group to propensity-matched historic control group.
Objective: To evaluate five-year results of single-level PEEK-on-ceramic cervical total disc replacement (TDR) compared with a propensity-matched anterior cervical discectomy and fusion (ACDF) control group.
Summary Of Background Data: Cervical TDR has gained acceptance as a treatment for symptomatic disk degeneration.
Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances.
Materials (Basel)
January 2024
Interfaces, Confinement, Matériaux et Nanostructures (ICMN), CNRS-Université d'Orléans, UMR 7374, 45071 Orleans, France.
In this work, a water-soluble (hydrophilic) polymer was used to form a hydrophobic coating on silicon substrates (Si) in a two-step process comprising (i) the transformation of the polymer into an insoluble material and (ii) the structuring of this coating at nanometric and micrometric scales to achieve the desired hydrophobic behavior. Polyvinylpyrrolidone (PVP), a water-soluble commodity polymer, was crosslinked using benzophenone and UV irradiation to produce a water-insoluble PVP coating. The nanometric scale roughness of the coating was achieved by the addition of silica nanoparticles (NPs) in the coating.
View Article and Find Full Text PDFOptimization and manufacture of polyetheretherketone patient specific cranial implants by material extrusion - A clinical perspective.
J Mech Behav Biomed Mater
August 2023
Research Unit Experimental Neurotraumatology, Department of Neurosurgery, Medical University of Graz, Auenbruggerplatz 2(9), 8036, Graz, Austria; BioTechMed-Graz, Graz, Austria.
Polyetheretherketone (PEEK) is a high performing thermoplastic that has established itself as a 'gold-standard' material for cranial reconstruction. Traditionally, milled PEEK patient specific cranial implants (PSCIs) exhibit uniform levels of smoothness (excusing suture/drainage holes) to the touch (<1 μm) and homogenous coloration throughout. They also demonstrate predictable and repeatable levels of mechanical performance, as they are machined from isotropic material blocks.
View Article and Find Full Text PDFSize-dominated biotoxicity of microplastics laden with benzophenone-3 and ciprofloxacin: Enhanced integrated biomarker evaluation on mussels.
Environ Pollut
September 2023
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Energy and Environmental Sustainability Solutions for Megacities, Campus for Research Excellence and Technological Enterprise, Singapore, 138602, Singapore. Electronic address:
Microplastics (MPs) are emerging pollutants with diverse sizes in aquatic environments. This paper investigates the toxicity of micron- and nano-scale polystyrene (50 μm, 5 μm, 0.5 μm) loaded with 2-hydroxy-4-methoxy-benzophenone (BP-3) and ciprofloxacin (CIP) by eight biomarker responses in mussels, perna viridis.
View Article and Find Full Text PDFFinancial implications of protocol-based hypertension treatment: an insight into medication costs in public and private health sectors in India.
J Hum Hypertens
September 2023
Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
Hypertension is a major public health challenge in low- and middle-income countries (LMICs) and calls for large-scale effective hypertension control programs. Adoption of drug and dose-specific treatment protocols recommended by the World Health Organization-HEARTS Initiative is key for hypertension control programs in LMICs. We estimated the annual medication cost per patient using three such protocols (protocol-1 and protocol-2 with Amlodipine, Telmisartan, using add-on doses and different drug orders, adding Chlorthalidone; protocol-3 with a single-pill combination (SPC) of Amlodipine/Telmisartan with dose up-titration, and addition of Chlorthalidone, if required) in India.
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