Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jm00287a023 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bromine signature coded derivatization LC-MS for specific profiling of carboxyl or carbonyl-containing metabolites in Mycoplasma pneumoniae infection.
Talanta
April 2025
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, 999078, China. Electronic address:
Carboxyl or carbonyl-containing metabolites (CoCCMs) are widely distributed in biological samples. Global profiling of CoCCMs is essential for ascertaining specific functions of metabolites and their potential physiological roles in biogenic activities. However, simultaneous determination of these compounds is hampered by poor ionization efficiency, vast polarity differences, wide discrepancy of concentration ranges.
View Article and Find Full Text PDFA Haloalkane Dehalogenase DhaA Nanoparticle Based on Pullulan Conjugation and Polyethyleneimine Adsorption.
Appl Biochem Biotechnol
November 2024
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
Haloalkane dehalogenase DhaA is a member of the α/β-hydrolase superfamily and can degrade the halogenated compounds. However, the enzyme could not tolerate harsh and extreme environmental conditions, such as high temperature, extreme pH, and hypersaline, which limits its practical applications. Pullulan is a hydrophilic polysaccharide and acts as an additive to improve the enzyme stability.
View Article and Find Full Text PDFMetabolite identification of emerging disinfection byproduct dibromo-benzoquinone in vivo and in vitro: Multi-strategy mass-spectrometry annotation and toxicity characterization.
Environ Int
November 2024
College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou, Zhejiang 310058, China. Electronic address:
Halobenzoquinones (HBQs) are emerging disinfection byproducts (DBPs) of high toxicity and also are shared active toxic intermediates of multiple halogenated organic pollutants. Due to the strong oxidizing property and electrophilicity, HBQs exhibit extremely diverse metabolism pathways in organisms. The identification of toxic-decisive metabolites is pivotal, albeit challenging, for understanding the toxicity mechanisms of HBQs.
View Article and Find Full Text PDFExposure to an environmentally representative mixture of polybrominated diphenyl ethers (PBDEs) alters zebrafish neuromuscular development.
Neurotoxicology
December 2024
INRS - Centre Armand Frappier Santé Biotechnologie, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada. Electronic address:
Polybrominated diphenyl ethers (PBDEs) are a prevalent group of brominated flame retardants (BFRs) added to several products such as electronics, plastics, and textiles to reduce their flammability. They are reported as endocrine disruptors and neurodevelopmental toxicants that can accumulate in human and wildlife tissues, thus making their ability to leach out of products into the environment a great cause for concern. In this study, zebrafish (Danio rerio) embryos and larvae were exposed to a wide concentration range (1.
View Article and Find Full Text PDFFirst insight into the environmental fate of N-acetylated sulfonamides from wastewater disinfection to solar-irradiated receiving waters.
J Hazard Mater
December 2024
Fujian Key Laboratory of Coastal Pollution Prevention and Control, College of the Environment & Ecology, Xiamen University, Xiamen 361102, PR China. Electronic address:
Article Synopsis
- Emerging transformation products of organic micropollutants, like N-acetylated sulfonamides (N-AcSAs), raise concerns due to their unknown environmental impacts and toxicity.
- The study investigated the reaction kinetics and mechanisms of N-AcSAs in various treatments, including chlorination, photodegradation, and solar treatments, revealing that the reactions are pH-dependent and dominated by specific oxidants.
- Results indicate that while solar-based methods can eliminate N-AcSAs, the transformation processes generate persistent and toxic secondary products, highlighting the need for better management and risk assessment of these byproducts.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!