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An improved matrix deposition technique for thin layer chromatography coupled to MALDI-TOF mass spectrometry (TLC-MALDI).
J Chromatogr A
December 2024
Freie Universität Berlin, Institut für Chemie und Biochemie, Thielallee 63, 14195 Berlin, Germany.
Analytical thin layer chromatography (TLC) is a simple yet powerful chromatographic technique that is widely used for the qualitative characterization of complex mixtures such as plant extracts. For their qualitative and visual characterisation, a large number of more or less specific colour reactions are at hand and numerous reference substances are available as well. However, the identification of extract components by colour and the comparison of retention times is not straightforward.
View Article and Find Full Text PDFGreen and High Throughput HPTLC Method for Simultaneous Estimation of Celecoxib and Tramadol Hydrochloride in their Newly Approved Analgesic Combination and Spiked Plasma with Dichromic Green and Blue Assessments.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia Street, Beside Green Plaza Complex 21648, Alexandria, Egypt.
The FDA "Food and Drug Administration" recently approved a novel co-crystal formulation of Celecoxib (CEX) and Tramadol (TRM) for the treatment of adults suffering from moderate to severe pain in several conditions. This novel combination has advantages over co-administration of the two drugs individually as better patient compliance, synergism and lower therapeutic cost. This work presents the first "High performance Thin Layer Chromatographic" (HPTLC) quantitative analytical technique for CEX and TRM simultaneous assay in bulk, their new dosage form and plasma.
View Article and Find Full Text PDFTLC densitometric approach for concurrent determination of quinary mixture for treatment of migraine with appraisal to method greenness and whiteness.
Sci Rep
December 2024
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Al Shaheed Shehata Ahmed Hegazy Street, Beni-Suef, 62514, Egypt.
A new accurate, precise thin layer chromatographic (TLC densitometric) approach was developed for the simultaneous analysis of ergotamine tartrate (ERG), phenobarbital sodium (PHEN), caffeine anhydrous (CAF), dipyrone sodium (DIP) and meprobamate (MEP) in their pure form and in their combined formulation; (MIGRANIL tablets). TLC separation depended on using a stationary phase of TLC plates F (20 × 10 cm) and using a developing system of ethyl acetate: methanol: n- hexane (8:2:3, by volume) with UV scanning at 254 nm for ERG, PHEN, CAF and DIP. For MEP, detection was done at 560 nm after spraying with 0.
View Article and Find Full Text PDFDevelopment of validated HPTLC methods for determination of triterpenoids and flavan-3-ols in leaf and stembark of Dubard.
Nat Prod Res
December 2024
Department of Pharmacognosy and Phytochemistry, L.M. College of Pharmacy, Ahmedabad, India.
Dubard is a highly reputed medicinal plant of Ayurveda. In the current study, High-performance Thin-layer chromatographic (HPTLC) techniques were established for the analysis of triterpenoids like lupeol (LU), betulinic acid (BA), epimeric flavan-3-ols (+)-catechin (CA), and (-)-epicatechin (ECA), in its leaf and stembark. HPTLC separation was performed using petroleum ether: ethyl acetate: toluene: formic acid (7:2:1:0.
View Article and Find Full Text PDFAn Electrochemical Pipette for the Study of Drug Metabolite.
Anal Chem
December 2024
Division of Energy, Matter and Systems, School of Science and Engineering, University of Missouri-Kansas City, Kansas City, Missouri 64110, United States.
Article Synopsis
- * A new thin-layer electrode (TLE) enables flexible experimental designs to observe reaction mechanisms of drug metabolites in a time-sensitive manner, which is crucial for accurate analysis.
- * The TLE, when used with a microelectrode, allows detailed study of drug metabolic oxidation, exemplified by the oxidation of acetaminophen and related drugs, facilitating structural analysis of reaction intermediates and products.
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