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Drug-induced Parkinson-like events: a real-world study from 2004 to the first quarter of 2024 based on FAERS.
Front Pharmacol
January 2025
Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Background: Timely identification of drug-induced Parkinson-like events is essential to improve clinical management and enhance patients' quality of life. However, there is a significant lack of studies addressing these events in real-world settings.
Methods: To bridge this gap, we analyzed adverse event (AE) reports related to Parkinson-like events from the FDA Adverse Event Reporting System (FAERS) database from the first quarter of 2004 to the first quarter of 2024.
In the later stages of Parkinson's disease (PD), patients often manifest levodopa-induced dyskinesia (LID), compromising their quality of life. The pathophysiology underlying LID is poorly understood, and treatment options are limited. To move toward filling this treatment gap, the intrinsic and synaptic changes in striatal spiny projection neurons (SPNs) triggered by the sustained elevation of dopamine (DA) during dyskinesia were characterized using electrophysiological, pharmacological, molecular and behavioral approaches.
View Article and Find Full Text PDFextract ameliorates motor dysfunc-tion in mouse Parkinsons disease model through inhibiting neuronal apoptosis.
Zhejiang Da Xue Xue Bao Yi Xue Ban
January 2025
School of Medicine, Hangzhou City University, Zhejiang Provincial Key Laboratory of Novel Targets and Drug Study for Neural Repair, Hangzhou 310015, China.
Objectives: To investigate the protective effects and underlying mechanisms of extract on motor dysfunction in mouse model of Parkinson's disease (PD).
Methods: Eighty C57BL/6 male mice were randomly divided into five groups: control group, PD model group, levodopa treatment group (positive control group), low-dose GP treatment group (LD-GP group), and high-dose GP treatment group (HD-GP group), with 16 mice per group. The PD model was induced by injection of 6-hydroxydopamine into the substantia nigra pars reticulata in mice of last 5 groups.
[Two years' experience with levodopa-entacapone-carbidopa intestinal gel treatment in advanced Parkinson's disease].
Orv Hetil
January 2025
1 Universitatea de Medicină, Farmacie, Științe și Tehnologie "George Emil Palade" din Târgu Mures (Marosvásárhelyi George Emil Palade Orvosi, Gyógyszerészeti, Tudomány és Technológiai Egyetem) Marosvásárhely, Gral Ion Dumitrache u. 20/A, 540081 Romania.
Potential of soybean-velvet bean combination tempe in improving cognitive function.
Narra J
December 2024
Department of Nutrition, Faculty of Medicine Science, Universitas Brawijaya, Malang, Indonesia.
Velvet bean is a native Indonesian legume containing L-dopa, yet it remains underutilized. The aim of this study was to analyze the effects of different types of tempe (soybean, velvet bean, and their combination) on cognitive function, brain histology, dopamine levels, and serum β-amyloid in rats, as well as to identify the parameters most influencing cognitive function, including brain mass and volume, hippocampal neuron count, and dopamine and β-amyloid levels. An experimental study was conducted using a completely randomized design with one factor: the protein source of diet.
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