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Highly multiplexed design of an allosteric transcription factor to sense new ligands.
Nat Commun
November 2024
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Article Synopsis
- * The study introduces Sensor-seq, a high-throughput platform that allows for the design and identification of aTF biosensors that can bind to a variety of non-native ligands, testing 17,737 variants of aTF TtgR against multiple compounds.
- * Sensor-seq successfully finds biosensors with high performance for various ligands and showcases their practical use through cell-free detection systems for specific drugs, enhancing the ability to create new biosensors beyond natural limitations.
A Review of Dextromethorphan-Quinidine for the Treatment of Agitation in Dementia.
Prim Care Companion CNS Disord
November 2024
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
To provide an updated summary of the literature on dextromethorphan quinidine for the treatment of agitation in dementia. PubMed, Medline, APA PsycINFO, Embase, and Cochrane Collaboration were searched from inception to January 7, 2024 using the keywords , , and . The search was limited to the English language and human subjects.
View Article and Find Full Text PDFBitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors.
Sci Rep
August 2024
Institute for Anatomy and Cell Biology, Philipps-University, Marburg, Germany.
Disorders of gallbladder motility can lead to serious pathology. Bitter tastants acting upon bitter taste receptors (TAS2R family) have been proposed as a novel class of smooth muscle relaxants to combat excessive contraction in the airways and other organs. To explore whether this might also emerge as an option for gallbladder diseases, we here tested bitter tastants for relaxant properties and profiled Tas2r expression in the mouse gallbladder.
View Article and Find Full Text PDFQuantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats.
Mol Pharm
May 2024
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
In recent years, the drainage of fluids, immune cells, antigens, fluorescent tracers, and other solutes from the brain has been demonstrated to occur along lymphatic outflow pathways to the deep cervical lymph nodes in the neck. To the best of our knowledge, no studies have evaluated the lymphatic transport of therapeutics from the brain. The objective of this study was to determine the lymphatic transport of model therapeutics of different molecular weights and lipophilicity from the brain using cervical lymph cannulation and ligation models in rats.
View Article and Find Full Text PDFDoxycycline diminishes the rewarding and psychomotor effects induced by morphine and cocaine.
Prog Neuropsychopharmacol Biol Psychiatry
January 2024
Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:
Few pharmacological treatments are available for substance use disorders (SUDs). Neuroplastic changes induced by increased activity of metalloproteinase (MMP) enzymes in the brain are among the several molecular processes that may play a role in drug addiction. Doxycycline, a widely used tetracycline that crosses the blood-brain barrier, inhibits MMPs and has been investigated as a potential treatment for brain disorders.
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