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New Engineered-Chimeric Botulinum Neurotoxin Mutant Acts as an Effective Bivalent Vaccine Against Botulinum Neurotoxin Serotype A and E.
Immunology
January 2025
Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, China.
Botulinum neurotoxins (BoNTs), including serotypes A and E, are potent biotoxins known to cause human poisoning. In addition to the critical protective antigen found in the full BoNT molecule, the receptor binding domain (Hc domain), BoNTs also harbour another essential protective antigen-the light chain-translocation domain (L-HN domain). Leveraging these pivotal protective antigens, we genetically engineered a series of inactivated chimeric molecules incorporating L-HN and Hc domains of BoNT/A and E.
View Article and Find Full Text PDFEnvironmental drivers of Euphorbia resinifera seed germination and seedling establishment for conservation purpose.
Braz J Biol
September 2024
Sultan Moulay Slimane University, Polydisciplinary Faculty, Polyvalent Team in Research and Development, Beni Mellal, Morocco.
Euphorbia resinifera O. Berg is a prickly, leafless and succulent, Moroccan endemic shrub. Field data indicate that the plant faces many challenges related to its natural regeneration and its gradual decline that can lead to a probability of extinction, at least in some areas.
View Article and Find Full Text PDFHuman CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains.
Nat Commun
May 2024
Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.
Article Synopsis
- The study focuses on the challenge of generating tier-2-neutralizing antibodies for HIV vaccines, highlighting the isolation of a specific antibody, HmAb64, from an immunized individual.
- HmAb64 is characterized by its unique genetic structure, derived from germline genes, and was shown to neutralize 10% of the tested HIV-1 pseudo-virus strains.
- The research also reveals the structural details of how HmAb64 binds to the CD4-binding site, proving that a gp120-based vaccine can effectively stimulate the production of antibodies capable of neutralizing tier-2 HIV strains.
Polyvalent Aptamer-Functionalized NIR-II Quantum Dots for Targeted Theranostics in High PD-L1-Expressing Tumors.
ACS Appl Mater Interfaces
May 2024
Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China.
AgS quantum dots (QDs) show superior optical properties in the NIR-II region and display significant clinical potential with favorable biocompatibility. However, inherent defects of low targeting and poor solubility necessitate practical modification methods to achieve the theranostics of AgS QDs. Herein, we used rolling circle amplification (RCA) techniques to obtain long single-stranded DNA containing the PD-L1 aptamer and C-rich DNA palindromic sequence.
View Article and Find Full Text PDFMg- or Ca-regulated aptamer adsorption on polydopamine-coated magnetic nanoparticles for fluorescence detection of ochratoxin A.
Mikrochim Acta
February 2024
Department of Instrumentation and Analytical Chemistry, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, People's Republic of China.
It has been observed that polyvalent metal ions can mediate the adsorption of DNA on polydopamine (PDA) surfaces. Exploiting this, we used two divalent metal ions (Mg or Ca) to promote the adsorption of fluorescence-labelled ochratoxin A (OTA) aptamers on PDA-coated magnetic nanoparticles (FeO@PDA). Based on the different adsorption affinities of free aptamers and OTA-bound aptamers, a facile assay method was established for OTA detection.
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