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Visual activity enhances neuronal excitability in thalamic relay neurons.
Sci Adv
January 2025
Aix-Marseille Université, INSERM, UNIS, Marseille, France.
Amblyopia, a highly prevalent loss of visual acuity, is classically thought to result from cortical plasticity. The dorsal lateral geniculate nucleus (dLGN) has long been held to act as a passive relay for visual information, but recent findings suggest a largely underestimated functional plasticity in the dLGN. However, the cellular mechanisms supporting this plasticity have not yet been explored.
View Article and Find Full Text PDFInorganic nitrogen and organic matter jointly regulate ectomycorrhizal fungi-mediated iron acquisition.
New Phytol
January 2025
North Florida Research and Education Center, University of Florida, 155 Research Road, Quincy, FL, 32351, USA.
Ectomycorrhizal fungi (EMF) play a crucial role in facilitating plant nutrient uptake from the soil although inorganic nitrogen (N) can potentially diminish this role. However, the effect of inorganic N availability and organic matter on shaping EMF-mediated plant iron (Fe) uptake remains unclear. To explore this, we performed a microcosm study on Pinus taeda roots inoculated with Suillus cothurnatus treated with +/-Fe-coated sand, +/-organic matter, and a gradient of NHNO concentrations.
View Article and Find Full Text PDFImpact of Soil Factors and Climate on Phytochemical Characteristics of Stachyslavandulifolia Vahl.
Chem Biodivers
January 2025
Sari Agricultural Sciences and Natural Resources University, Rangeland Sciences, sari, IRAN, ISLAMIC REPUBLIC OF.
This study investigates the influence of environmental factors on the secondary metabolites of Stachyslavandulifolia Vahl., focusing on how soil properties, temperature, and precipitation affect the yield and chemical composition of its essential oils. The research was conducted in two domains within three rangelands in Mazandaran province, Iran.
View Article and Find Full Text PDFTen Machine Learning Models for Predicting Preoperative and Postoperative Coagulopathy in Patients With Trauma: Multicenter Cohort Study.
J Med Internet Res
January 2025
Department of Anesthesiology, Daping Hospital, Army Medical University, Chongqing, China.
Background: Recent research has revealed the potential value of machine learning (ML) models in improving prognostic prediction for patients with trauma. ML can enhance predictions and identify which factors contribute the most to posttraumatic mortality. However, no studies have explored the risk factors, complications, and risk prediction of preoperative and postoperative traumatic coagulopathy (PPTIC) in patients with trauma.
View Article and Find Full Text PDFEmpagliflozin Reduces High Glucose-Induced Cardiomyopathy in hiPSC-Derived Cardiomyocytes : Glucose-induced Lipotoxicity in hiPSC-Derived Cardiomyocytes.
Stem Cell Rev Rep
January 2025
Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Human-induced pluripotent stem cell (hiPSC) technology has been applied in pathogenesis studies, drug screening, tissue engineering, and stem cell therapy, and patient-specific hiPSC-derived cardiomyocytes (hiPSC-CMs) have shown promise in disease modeling, including diabetic cardiomyopathy. High glucose (HG) treatment induces lipotoxicity in hiPSC-CMs, as evidenced by changes in cell size, beating rate, calcium handling, and lipid accumulation. Empagliflozin, an SGLT2 inhibitor, effectively mitigates the hypertrophic changes, abnormal calcium handling, and contractility impairment induced by HG.
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