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Histone methyltransferase KMT2A promotes pulmonary fibrogenesis via targeting pro-fibrotic factor PU.1 in fibroblasts.
Clin Transl Med
February 2025
Department of Pulmonary and Critical Care Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Background: Idiopathic pulmonary fibrosis (IPF) is a fibrotic disease driven by both environmental and genetic factors. Epigenetics refers to changes in gene expression or cellular phenotype that do not involve alterations to DNA sequence. KMT2A is a member of the SET family which catalyses H3K4 methylation.
View Article and Find Full Text PDFSex-related changes in lactate dehydrogenase A expression differently impact the immune response in melanoma.
FEBS J
January 2025
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy.
Melanoma is more aggressive in male patients than female ones and this is associated with sexual dimorphism in immune responses. Taking into consideration the impact tumour metabolic alterations in affecting the immune landscape, we aimed to investigate the effect of the sex-dependent metabolic profile of melanoma in re-shaping immune composition. Melanoma is characterised by Warburg metabolism, and secreted lactate has emerged as a key driver in the establishment of an immunosuppressive environment.
View Article and Find Full Text PDFInvestigation of Substance Basis and Pharmacodynamics of Qingzao Jiefei Decoction in Lung Cancer based on Serum Pharmacochemistry and Proteomics.
Chem Biodivers
January 2025
Jiangxi University of Chinese Medicine, Research Center for Differentiation and Development of CM Basic Theory of Jiangxi University of Chinese Medicine, Jiangxi Province Key Laboratory of CM Etiopathogenesis, Nanchang, Jiangxi, China, 330004, 330004, nan chang, CHINA.
Qingzao Jiufei Decoction (QD) is a renowned prescription for nourishing lung Yin to treat lung related diseases in ancient and modern times. It has been reported that QD can effectively inhibit the growth of lung cancer, but the material basis and mechanism of its treatment of LC remain to be further studied. In this experiment, we combined serum pharmacochemistry and proteomics to study the pharmacodynamic material basis and mechanism of QD against lung cancer.
View Article and Find Full Text PDFArterial Stiffness and Markers of Atrial Myopathy.
Ann Noninvasive Electrocardiol
March 2025
Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
Background: Arterial stiffness, measured using carotid-femoral pulse wave velocity (c-f PWV) and heart rate-corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (AF). In this cross-sectional study, we aimed to investigate whether arterial stiffness is associated with markers of atrial myopathy, which refers to structural and electrical changes in the atria that indicate increased AF risk.
Methods: We included 1050 participants (age 57 ± 4.
Body composition alterations in patients with lung cancer.
Am J Physiol Cell Physiol
January 2025
Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Most patients with lung cancer experience cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting. Knowledge of body composition changes in patients is limited, however, because most studies have been cross-sectional, comparing patients with non-cancer controls or patients with and without CC. Few studies, in contrast, have evaluated body composition in patients with lung cancer over time.
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