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Matching model with mechanism: Appropriate rodent models for studying various aspects of diabetes pathophysiology.
Methods Cell Biol
January 2025
School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, United Kingdom. Electronic address:
Many rodent models are available for preclinical diabetes research making it a challenge for researchers to choose the most appropriate one for their experimental question. To aid in this, models have classically been categorized according to which type of diabetes they represent, and further into whether the model is induced, spontaneous or the result of genetic manipulation. This fails to capture the complexity of pathogenesis seen in diabetes in humans.
View Article and Find Full Text PDFExploring a Software Framework for Posture Tracking and Haptic Feedback Control: A Virtual Reality-Based Approach for Upper Limb Rehabilitation on the Oculus Quest 2.
Sensors (Basel)
January 2025
2Ai, School of Technology, IPCA, 4750-810 Barcelos, Portugal.
Virtual reality (VR) has gained significant attention in various fields including healthcare and industrial applications. Within healthcare, an interesting application of VR can be found in the field of physiotherapy. The conventional methodology for rehabilitating upper limb lesions is often perceived as tedious and uncomfortable.
View Article and Find Full Text PDFUnderstanding the Intricate Pathophysiology of Psoriasis and Related Skin Disorders.
Int J Mol Sci
January 2025
Department of Dermatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Psoriasis is a chronic inflammatory condition that is polygenic and multisystemic, impacting approximately 2-3% of the global population. The onset of this disease is influenced by an intricate interplay of genetic and environmental factors, predisposing individuals to the psoriasis phenotype. The complex pathogenesis of psoriasis contains certain key aspects found in other autoinflammatory and autoimmune dermatological diseases.
View Article and Find Full Text PDFRelationship Between Perilesional Skin Condition and Survival in Terminally Ill Patients with Pressure Ulcers.
Medicina (Kaunas)
January 2025
SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, 46001 Valencia, Spain.
In the context of palliative care, the aim is to alleviate suffering and improve quality of life, with particular attention to PUs, which have a significant impact on quality of life and survival. This study examines the relationship between perilesional skin condition and survival in terminally ill patients with pressure ulcers (PUs). A descriptive and observational study was conducted in two hospitals in Valencia with a sample of 100 terminally ill patients.
View Article and Find Full Text PDFPreferential Sites of Retinal Capillary Occlusion in Sickle Cell Disease.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States.
Purpose: To assess the preferential sites of retinal capillary occlusion at the parafovea in patients with sickle cell disease (SCD) using optical coherence tomography angiography (OCT-A).
Methods: OCT-A scans from 107 patients with SCD and 51 race-matched unaffected controls were obtained using a commercial spectral domain-OCT system. At least eight sequential 3 × 3 mm scans centered at the fovea were acquired and averaged for image analysis.
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