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An 80-year-old woman with epigastric pain and weight loss presented to our hospital with cancer of the ascending colon and cholelithiasis. Initially hospitalized for a suspected gallstone attack, she later developed gangrenous cholecystitis. She underwent a laparoscopic cholecystectomy, which revealed abscess formation and necrosis extending into the gallbladder duct.

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Laparoscopic cholecystectomy is the preferred method for treating acute cholecystitis. Although the incidence of postoperative infections in laparoscopic cholecystectomy is low, serious postoperative surgical site infections are still reported. Hepatic abscesses, particularly fungal, can occur post-cholecystectomy leading to significant mortality and morbidity.

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Article Synopsis
  • Gallstone disease significantly strains healthcare resources, particularly through emergency cholecystectomy, yet there's limited research on the risk factors that lead to such emergencies in patients scheduled for elective surgery.
  • A study conducted in Jeddah, Saudi Arabia, analyzed 823 patients, revealing that 15.67% underwent emergency cholecystectomy, often due to longer waiting times and previous emergency department visits.
  • Key findings indicated that patients with acute cholecystitis or pancreatitis, and those with multiple prior ED visits, are at a much higher risk of requiring emergency surgery.
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Background: Mood instability, characterized by sudden and unpredictable mood shifts, is prevalent in psychiatric disorders and as a personality trait. Its association with gastrointestinal diseases has been recognized but remains poorly understood in terms of causality.

Methods: This study aims to investigate the causal relationship between mood instability and a spectrum of gastrointestinal diseases by univariable and multivariable mendelian randomization analysis.

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We report the case of a 76-year-old man who presented with pain in the right upper abdomen. Laboratory and radiological examinations revealed cholangitis, cholelithiasis, and a gallbladder tumor adhering to the transverse colon. After receiving conservative therapy for cholangitis, the patient underwent surgery for the gallbladder disease.

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