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Is It Enough to Diagnose Pheochromocytoma by Measuring Urine Metanephrines Levels?
Cureus
September 2024
Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University School of Medicine, Ankara, TUR.
Article Synopsis
- - This study evaluated the effectiveness of plasma and urinary metanephrines as diagnostic tools for adrenal lesions in 152 patients, highlighting their importance in a multidisciplinary medical setting.
- - A variety of adrenal conditions were identified among patients, including pheochromocytoma and adrenocortical carcinoma, with 94 patients undergoing surgery.
- - Urinary fractionated metanephrine was found to be the most sensitive test for diagnosing pheochromocytoma (90%), while plasma free normetanephrine was the most specific (91.4%), demonstrating a significant correlation between the plasma and urinary tests.
Differential involvement of central and peripheral catecholamines between Alzheimer's disease and vascular dementia.
Heliyon
October 2024
Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, 430071, Hubei, China.
Article Synopsis
- The study investigates the role of catecholamines (like dopamine and norepinephrine) in the development of Alzheimer's disease (AD) and vascular dementia (VaD) by analyzing their levels in animal models.
- Using specific mouse and rat models, researchers measured catecholamine concentrations in both blood and different brain areas to understand their distribution and expression during these neurodegenerative processes.
- Findings reveal that while catecholamines like dopamine are significant in AD, VaD is more associated with changes in the central noradrenergic system and increased serum catecholamines, suggesting different treatment approaches may be needed for each condition.
A Rare Case of Paraganglioma Syndrome Associated With Polycythemia and Blindness.
Cureus
June 2024
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Rochester Medical Center, Rochester, USA.
Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors. They can be diagnosed independently or as part of a syndrome, especially with germline mutations. Rarely, a somatic mutation can present as part of a syndrome associated with recurrent PPGL, congenital polycythemia, and vascular malformation.
View Article and Find Full Text PDFLate-Onset Manifestations of Von Hippel-Lindau Syndrome: A Case Report.
Cureus
June 2024
Radiology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University), Pune, IND.
Von Hippel-Lindau (VHL) syndrome is characterized by a range of tumors including phaeochromocytomas, pancreatic adenomas, cerebellar haemangioblastomas, and renal cell carcinomas. A 50-year-old male presented with a three-week history of headache. Additionally, the patient exhibited signs of hypertension.
View Article and Find Full Text PDF[The relationship between clinical characteristics and pathological features in patients with pheochromocytomas/paragangliomas].
Zhonghua Yi Xue Za Zhi
July 2024
Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People's Republic of China, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
To explore the correlation between clinical characteristics and pathological features in patients with pheochromocytoma/paraganglioma (PPGLs). A case series study. A retrospective analysis was conducted on patients with single and primary PPGLs after postoperative pathological diagnosis who were admitted to Peking Union Medical College Hospital between January 2019 and December 2022.
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