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Echinops Asteraceae extract guards against malathion-induced liver damage via minimizing oxidative stress, inflammation, and apoptosis.
Toxicon
June 2024
King Khalid University, Faculty of Sciences, Biology Department, Abha, Kingdom of Saudi Arabia; Mansoura University, Faculty of Sciences, Department of Zoology, Mansoura, Egypt. Electronic address:
Malathion (MAL) is one of the highly toxic organophosphorus (OP) compounds that induces hepatotoxicity. Echinops. ritro leaves extract (ERLE) is traditionally used in the treatment of bacterial/fungal infections.
View Article and Find Full Text PDFLower malathion concentrations reduce testosterone biosynthesis by Leydig TM3 cells in vitro by altering cellular redox profile and inducing oxidative damage.
Reprod Toxicol
June 2024
Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Rodovia Celso Garcia Cid, PR 445, Londrina, Paraná 86057-970, Brazil.
Malathion is an organophosphate pesticide used in agriculture and control of the Aedes aegypti mosquito. As previous reports have indicated the potential of malathion to compromise testosterone production in in vivo models, the objective of this study was to elucidate the mechanisms underlying the impairment of Leydig cell function, considering its critical role in male reproductive function. To this end, murine Leydig TM3 cells were exposed to concentrations of 1, 10, 100 or 1000 μM malathion for 24 h for evaluation of the compound on cell viability.
View Article and Find Full Text PDFMetabolism of Tembotrione, a Triketone Herbicide, confers Differential Sensitivity in Winter Wheat ().
J Agric Food Chem
April 2024
Department of Agronomy, Kansas State University, Manhattan, Kansas 66506-0100, United States.
Tembotrione is a triketone herbicide widely used for broad-spectrum weed control in corn but not registered for use in wheat. A wide collection of spring, winter, and EMS-derived mutant lines of wheat was evaluated for their response to tembotrione treatment. Two winter wheat (WW) genotypes (WW-1 and WW-2) were found to be least sensitive to this herbicide, surviving >6 times the field recommended dose (92 g ai ha) compared to the most sensitive genotype (WW-24).
View Article and Find Full Text PDFLow doses of malathion impair ovarian, uterine, and follicular integrity by altering oxidative profile and gene expression of rats exposed during the peripubertal period.
Environ Sci Pollut Res Int
March 2024
Department of General Biology, Biological Sciences Center, State University of Londrina (UEL), Rodovia Celso Garcia Cid, PR 445, Londrina, Paraná, 86057-970, Brazil.
Malathion serves as a pivotal pesticide in agriculture and the management of the Aedes aegypti mosquito. Despite its widespread use, there is a notable absence of studies elucidating the mechanisms through which malathion may affect the female reproductive system. Consequently, the objective of this investigation was to assess whether exposing juvenile female rats to low doses of malathion during the juvenile and peripubertal periods could compromise pubertal onset, estradiol levels, and the integrity of the ovaries and uterus while also examining the underlying mechanisms of damage.
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