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Dynamic pathophysiological features of early primary blast lung injury: a novel functional incapacity pig model.
Eur J Trauma Emerg Surg
January 2025
Department of Military Traffic Injury Prevention and Control, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Introduction: While there is evidence supporting the use of ultrasound for real-time monitoring of primary blast lung injury (PBLI), uncertainties remain regarding the timely detection of early PBLI and the limited data correlating it with commonly used clinical parameters. Our objective is to develop a functional incapacity model for PBLI that better addresses practical needs and to verify the early diagnostic effectiveness of lung ultrasound in identifying PBLI.
Methods: We selected six healthy male pigs to develop an animal model using a bio-shock tube (BST-I).
Cerebrovascular Accidents After Orthotopic Liver Transplantation in Patients with Hepatopulmonary Syndrome: A Case Series.
Clin Pract
December 2024
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Hepatopulmonary syndrome (HPS), defined by the presence of pulmonary vascular dilatations that cause right-to-left transpulmonary shunting of venous blood with a consequential increase in the alveolar-arterial oxygen gradient, is a relatively frequent complication of chronic liver disease. While orthotopic liver transplantation (OLT) is indicated and often curative in HPS patients with end-stage liver disease (ESLD), little is known about the peri- and post-operative-period risks of CVA in OLT recipients with HPS. : We report a case series of five non-consecutive OLT recipients with HPS who developed ischemic and/or hemorrhagic CVAs during or shortly after OLT, raising concern that the risks of neurological complications remain increased even after OLT.
View Article and Find Full Text PDFDiagnostic Value of the Alveolar-Arterial Oxygen Gradient in Pulmonary Embolism: A Cross-Sectional Study.
Healthcare (Basel)
December 2024
School of Medicine, University of Split, 21000 Split, Croatia.
: Pulmonary embolism (PE) is a potentially serious condition characterized by the blockage of blood vessels in the lungs, often presenting significant diagnostic challenges due to its non-specific symptoms. This study aimed to evaluate the utility of the alveolar-arterial (A-a) oxygen gradient as a diagnostic tool for PE, hypothesizing that it could enhance early detection when combined with other clinical markers. : We retrospectively analyzed 168 patients at the University Hospital Center Split.
View Article and Find Full Text PDFIndividual FiO guided by SO prevents hyperoxia and reduces postoperative atelectasis in colorectal surgery: A randomized controlled trial.
J Clin Anesth
February 2025
Department of Anesthesiology, Second Affiliated Hospital of Harbin Medical University, China; The Key Laboratory of Anesthesiology and Intensive Care Research of Heilongjiang Province, China. Electronic address:
Study Objective: To determine whether individualized fraction of inspired oxygen (iFiO) improves pulmonary atelectasis after elective laparoscopic colorectal surgery relative to 60 % FiO.
Design: This was a single-center, prospective, randomized study.
Setting: This study was conducted in a single tertiary care hospital in China.
Individualized positive end-expiratory pressure in laparoscopic surgery: a randomized controlled trial.
Minerva Anestesiol
November 2024
Department of Anesthesiology and Critical Care Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China -
Article Synopsis
- The study investigates how individualized positive end-expiratory pressure (PEEP), based on driving pressure, impacts lung function after laparoscopic colorectal surgery.
- A total of 91 patients were randomly assigned to receive either individualized PEEP or a fixed PEEP, with the main focus being on postoperative functional residual capacity (FRC) and other pulmonary outcomes.
- Results showed that individualized PEEP significantly increased postoperative FRC and improved other measures of lung function compared to the fixed PEEP group, indicating its effectiveness in enhancing ventilation and oxygenation.
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