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Cross-feeding of amino acid pathway intermediates is common in co-cultures of auxotrophic Escherichia coli.
Metab Eng
January 2025
Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA. Electronic address:
Amino acid auxotrophy refers to an organism's inability to synthesize one or more amino acids that are required for cell growth. In microbiome research, co-cultures of amino acid auxotrophs are often used to investigate metabolite cross-feeding interactions and model community dynamics. Thus far, it has been implicitly assumed that amino acids are mainly cross-fed between these auxotrophs.
View Article and Find Full Text PDFProline-Rich Antimicrobial Peptides from Invertebrates.
Molecules
December 2024
Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19 St., 20-033 Lublin, Poland.
Antimicrobial peptides (AMPs) constitute a large and diverse group of molecules with antibacterial, antifungal, antiviral, antiprotozoan, and anticancer activity. In animals, they are key components of innate immunity involved in fighting against various pathogens. Proline-rich (Pr) AMPs are characterized by a high content of proline (and arginine) residues that can be organized into Pro-Arg-Pro motifs.
View Article and Find Full Text PDFUnraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis.
Front Immunol
January 2025
Integrated Metabolomics Research Group, Metropolitan Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea.
Introduction: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, notably delta and omicron, has significantly accelerated the global pandemic, worsening conditions worldwide. However, there is a lack of research concerning the molecular mechanisms related to immune responses and metabolism induced by these variants.
Methods: Here, metabolomics combined with transcriptomics was performed to elucidate the immunometabolic changes in the lung of hamsters infected with delta and omicron variants.
Identification of immunostimulatory activities and active compounds from sequentially extracted fractions of rhizosphere fungal fermentation broth of Koidz. rhizomes.
Front Pharmacol
December 2024
College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Introduction: Pharmacological studies have shown that the rhizome of Atractylodes macrocephala Koidz. (Compositae), commonly known as atractylodes macrocephala rhizome (AMR), can modulate immunity. Nevertheless, its resources have been largely depleted, and the pharmacological activity of artificial AMR is relatively modest.
View Article and Find Full Text PDF[Investigation of sasX, ACME and Various Virulence Factors in Coagulase Negative Staphylococcal Strains Identified as Bloodstream Infection Agents and Contamination].
Mikrobiyol Bul
October 2024
Pamukkale University Faculty of Medicine, Department of Medical Microbiology, Denizli, Türkiye.
The aim of this study was to investigate the frequency of sasX, arginine catabolic mobile element (ACME) genes, biofilm formation and some biofilm related virulence factor genes in causative and contaminant coagulase negative staphylococci (CNS) strains isolated from blood cultures. Of the 150 CNS strains included in the study, 50 were grouped as infectious agents and 100 as contaminants. Biofilm formation of the strains was investigated by microplate method and the presence of sasX, ACME, mecA and biofilm associated virulence factor genes icaA, icaD, aap, bhp and IS256 were investigated by inhouse polymerase chain reaction method.
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