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Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy.
EJNMMI Radiopharm Chem
January 2025
Department of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, 52750, Mexico.
Background: Cancer immunotherapy is a relatively new approach to cancer treatment. Peptides that target specific pathways and cells involved in immunomodulation can potentially improve the efficacy of cancer therapy. Recently, we reported iPD-L1 as a novel inhibitor peptide that specifically targets the cancer cell ligand PD-L1 (programmed death ligand 1).
View Article and Find Full Text PDFDetermination of optimal gamma radiation dose for mutation breeding in 'Sabz' fig (Ficus carica L.) cuttings based on radiosensitivity and phenotypic changes.
PLoS One
January 2025
Fig Research Station, Fars Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO), Estahban, Iran.
The dried fig cv. Sabz of Iran, distinguishes out among the several fig cultivars for its unique characteristics and excellent properties. The aims to this study were 1) Carefully monitoring the resulting phenotypic changes in growth patterns, leaf morphology, shoot traits, root characteristics, and other relevant traits after irradiated with different gamma rays; 2) Investigating the LD25, 50, 75 and GR25, 50, 75 values at different gamma radiation doses for chose optimum dose.
View Article and Find Full Text PDFComprehensive analysis of naturally occurring radionuclides in well water: Isotopic ratios, mitigation, and dose assessment.
Ecotoxicol Environ Saf
January 2025
Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg SE-413 45, Sweden.
In Sweden, around 20 % of the potable water comes from groundwater sources and about one million people drink water from their private wells. In areas with moderate or high abundance of naturally occurring radionuclides in the bedrock, the groundwater could be enhanced with radio and chemically toxic elements such as uranium, radium, lead and polonium. Therefore, this study aims to carry out a comprehensive analysis of the behaviour and radiological impact of naturally occurring radionuclides in well water.
View Article and Find Full Text PDFAssessment of radiological hazards in terms of gross α -β activities in groundwater in and around Beldih mine region of eastern India.
Environ Geochem Health
November 2024
Department of Physics, Sidho-Kanho-Birsha University, Purulia, 723104, India.
In the present study, liquid scintillation counting triple to double coincidence ratio technique is used to ascertain the gross α and β activity in groundwater samples collected from the Beldih mine region in the vicinity of the South Purulia Shear Zone (SPSZ) of Chota Nagpur Plateau in eastern India. A total of sixty samples were collected from deep tube wells located in the study area to assess the potential health threats caused by α and β emitting radionuclides present in these water samples. Average gross α activity in the region of study is 0.
View Article and Find Full Text PDFAssessing radioactivity levels in agricultural soil: a comparative study of traditional vs. modern fertilization techniques in Tunisian oases.
Environ Monit Assess
November 2024
Faculty of Science, Tunis El Manar University, LR11RS23, 1006, Tunis, Tunisia.
To establish a radiological national reference for agricultural soil across Tunisian oases and assess the risk to human health associated with date consumption, with a focus on comparing the impact of traditional and modern fertilization, radiological parameters and activity levels of ⁶Ra, Th, and ⁰K were determined for 27 oases. These oases were located in three southern Tunisian governorates. The activity concentration of ⁶Ra, Th, and ⁰K was measured using a 3 × 3 inch NaI(Tl) scintillation detector, which was found to be 21.
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